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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 311 - 316 (6page)
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초록· 키워드
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Sulforaphane (1-isothiocyanato-4-(methylsulfinyl)-butane), belonging to a family of natural compounds that are abundant in broccoli,has received significant therapeutic interest in recent years.
However, the molecular basis of its effects remains to be elucidated. In this study, we attempt to determine whether sulforaphane regulates the inflammatory response in an ovalbumin (OVA)-induced murine asthma model. Mice were sensitized with OVA, treated with sulforaphane, and then challenged with OVA. Sulforaphane administration significantly alleviated the OVA-induced airway hyperresponsiveness to inhaled methacholine.
Additionally, sulforaphane suppressed the increase in the levels of SOCS-3 and GATA-3 and IL-4 expression in the OVA-challenged mice. Collectively, our results demonstrate that sulforaphane regulates Th2 immune responses. This sutdy provides novel insights into the regulatory role of sulforaphane in allergen-induced Th2 inflammation and airway responses, which indicates its therapeutic potential for asthma and other allergic diseases. [BMB reports 2012; 45(5): 311-316]
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참고문헌 (24)
참고문헌 신청
Bousquet, J. / 1990 / Eosinophilic inflammation in asthma / N. Engl. J. Med. 323 : 1033 ~ 1039
Busse, W. W. / 1993 / Mechanism of airway inflammation in asthma / Am. Rev. Respir. Dis. 147 : S20 ~ S24
Chen, C. C. / 2004 / Flavonoids inhibit tumor necrosis factor- alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells thro
Corrigan, C. J. / 1992 / T cells and eosinophils in the pathogenesis of asthma / Immunol. Today 13 : 501 ~ 507
Grzelewska-Rzymowska, I. / 1996 / Chemotactic serum activity for neutrophils and eosinophils an
Busse, W. W. / 1993 / Mechanism of airway inflammation in asthma / Am. Rev. Respir. Dis. 147 : S20 ~ S24
Chen, C. C. / 2004 / Flavonoids inhibit tumor necrosis factor- alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells thro
Corrigan, C. J. / 1992 / T cells and eosinophils in the pathogenesis of asthma / Immunol. Today 13 : 501 ~ 507
Grzelewska-Rzymowska, I. / 1996 / Chemotactic serum activity for neutrophils and eosinophils an
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