지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 205 - 210 (6page)
이용수
초록· 키워드
오류제보하기
Insulin has antiapoptotic activity in various cell types. However,the signaling pathways underlying the antiapoptotic activity of insulin is not yet known. This study was conducted to determine if cAMP affects the antiapoptotic activity of insulin and the activity of PI3K and ERK in CHO cells expressing human insulin receptors (CHO-IR). Insulin-stimulated ERK activity was completely suppressed by cAMP-elevating agents like as pertussis toxin (Ptx) and cholera toxin (Ctx) after 4 h treatment.
Insulin-stimulated PKB/Akt activity was not affected at all. Ptx treatment together with insulin increased the number of apoptotic cells and the degree of DNA fragmentation. Ctx or 8-brcAMP treatment also increased the number of apoptotic cells and stimulated the cleavage of caspase-3 and the hydrolysis of PARP. Taken together, cAMP antagonizes the antiapoptotic activity of insulin and the main target molecule of cAMP in this process is likely ERK, not PI3K-dependent PKB/Akt. [BMB reports 2011; 44(3): 205-210]
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Baron, A. D / 1997 / Role of blood flow in the regulation of muscle glucose uptake / Annu. Rev. Nutr 17 : 487 ~ 499
Basso, A. D / 2006 / Lipid posttranslational modif
Cheatham, B / 1995 / Insulin action and the insulin signaling network / Endocr. Rev 16 : 117 ~ 142
Desbois-Mouthon, C / 2000 / Insulin-mediated cell proliferation and survival involve inhibition of c-Jun N-terminal kinases through a phosphatidylinositol 3-kinase- and mitog
Harris, I. S / 2004 / G-protein signaling participates in the development of diabetic cardiomyopathy / Diabetes 53 : 3082 ~ 3090
Basso, A. D / 2006 / Lipid posttranslational modif
Cheatham, B / 1995 / Insulin action and the insulin signaling network / Endocr. Rev 16 : 117 ~ 142
Desbois-Mouthon, C / 2000 / Insulin-mediated cell proliferation and survival involve inhibition of c-Jun N-terminal kinases through a phosphatidylinositol 3-kinase- and mitog
Harris, I. S / 2004 / G-protein signaling participates in the development of diabetic cardiomyopathy / Diabetes 53 : 3082 ~ 3090
이 논문의 저자 정보
최근 본 자료
댓글(0)
0