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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 182 - 186 (5page)
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Exogenous stimuli such as nerve growth factor (NGF) exert their effects on neurite outgrowth via Trk neurotrophin receptors.
TrkA receptors are known to be ubiquitinated via proteasome inhibition in the presence of NGF. However, the effect of proteasome inhibition on neurite outgrowth has not been studied extensively. To clarify these issues, we investigated signaling events in PC12 cells treated with NGF and the proteasome inhibitor MG132. We found that MG132 facilitated NGF-induced neurite outgrowth and potentiated the phosphorylation of the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways and TrkA receptors.
MG132 stimulated internalization of surface TrkA receptor and stabilized intracellular TrkA receptor, and the UbK63 chain was found to be essential for stability. These results indicate that the ubiquitin-proteasome system potentiated neurite formation by regulating the stability of TrkA receptors. [BMB reports 2011; 44(3): 182-186]
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참고문헌 (25)
참고문헌 신청
Alfa, R. W / 2009 / A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth / J. Neurosci. Res 87 : 2624 ~ 2631
Alwan, H. A / 2003 / Ligand-induced lysosomal epidermal growth factor receptor (EGFR) degradation is preceded by proteasomedependent EGFR de-ubiquitination / J. Biol. Chem 2
Bronfman, F. C / 2003 / Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome / J. Neurosci 23 : 3209 ~ 3220
Chao, M. V / 1995 / p75 and Trk: a two-receptor system / Trends Neurosci 18 : 321 ~ 326
Chen, Z. Y / 2005 / A novel endocytic recycling signal distinguishes biological responses of Trk neurotrophin receptors / Mol. Biol. Cell 6 : 5761 ~ 5772
Alwan, H. A / 2003 / Ligand-induced lysosomal epidermal growth factor receptor (EGFR) degradation is preceded by proteasomedependent EGFR de-ubiquitination / J. Biol. Chem 2
Bronfman, F. C / 2003 / Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome / J. Neurosci 23 : 3209 ~ 3220
Chao, M. V / 1995 / p75 and Trk: a two-receptor system / Trends Neurosci 18 : 321 ~ 326
Chen, Z. Y / 2005 / A novel endocytic recycling signal distinguishes biological responses of Trk neurotrophin receptors / Mol. Biol. Cell 6 : 5761 ~ 5772
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