지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 235 - 236 (2page)
이용수
초록· 키워드
오류제보하기
The circadian clock is an internal system that is synchronized by external stimuli, such as light and temperature, and influences various physiological and developmental processes in living organisms. In the model plant Arabidopsis, transcriptional, translational and post-translational processes are interlocked by feedback loops among morning- and eveningphased genes. In a post-translational loop, plant-specific singlegene encoded GIGANTEA (GI) stabilize the F-box protein ZEITLUPE (ZTL), driving the targeted-proteasomal degradation of TIMING OF CAB EXPRESSION 1 (TOC1) and PSEUDORESPONSE REGULATOR 5 (PRR5). Inherent to this, we demonstrate the novel biochemical function of GI as a chaperone and/or co-chaperone of Heat-Shock Protein 90 (HSP90). GI prevents ZTL degradation as a chaperone and facilitates ZTL maturation together with HSP90/HSP70, enhancing ZTL activity in vitro and in planta. GI is known to be involved in a wide range of physiology and development as well as abiotic stress responses in plants, but it could also interact with diverse client proteins to increase protein maturation. Our results provide evidence that GI helps proteostasis of ZTL by acting as a chaperone and a co-chaperone of HSP90 for proper functioning of the Arabidopsis circadian clock.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Dynamic Circadian Regulation and Modulator of Clock Genes in Skin Cells
한국생물공학회 학술대회
2021 .10
-
Improvement of Albumin-erythropoietin Production by Chemical Chaperone in CHO Cell Cultures
한국생물공학회 학술대회
2015 .04
-
A strategy for cell-free screening of molecular chaperones that assist proper folding of hard-to-express proteins
한국생물공학회 학술대회
2019 .04
-
Per-deuteration and NMR experiments for the backbone assignment of 62 kDa protein, Hsp31
Journal of the Korean Magnetic Resonance Society
2015 .01
-
Pairing of Orthogonal Chaperones with a Cytochrome P450 Enhances Terpene Synthesis in Saccharomyces cerevisiae
한국생물공학회 학술대회
2021 .10
-
Roles of circadian clocks in cancer pathogenesis and treatment
Experimental and Molecular Medicine
2021 .10
-
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1
Experimental and Molecular Medicine
2020 .01
-
RNA Folding and the Non-equilibrium Action of RNA Chaperones
한국고분자학회 학술대회 연구논문 초록집
2024 .09
-
Enhanced Total Activity of ChCODH by Co-expression of Suf System and Chaperone Proteins in Engineered Escherichia coli Under Microaerobic Conditions
한국생물공학회 학술대회
2022 .09
-
An Extended Plant Circadian Clock Model for Characterising Flowering Time under Different Light Quality Conditions
제어로봇시스템학회 국제학술대회 논문집
2022 .11
-
Development of a HER2-positive Tumor-targeted Delivery Platform for Various hsp90 Inhibitors
한국생물공학회 학술대회
2022 .04
-
ERK-dependent phosphorylation of the linker and substrate-binding domain of HSP70 increases folding activity and cell proliferation
Experimental and Molecular Medicine
2019 .01
-
Circadian Lighting
조명·전기설비
2019 .11
-
Screening of effective molecular chaperones by sequential cell-free protein synthesis reactions
한국생물공학회 학술대회
2018 .04
-
Circadian Rhythm and Human Health: Researches of BCA2-RLRC (Biological Clock-based Anti-Aging Convergence Regional Leading Research Center of NRF, Korea)
한국생물공학회 학술대회
2022 .09
-
Use of tandem cell-free protein synthesis reactions for rapid screening of effective molecular chaperones
한국생물공학회 학술대회
2018 .10
-
소의 열 스트레스와 유전자(총설)
동물자원연구
2015 .01
-
비SF6 가스적용 초고압 친환경 GIS 개발을 위한 드라이에어 절연 특성
대한전기학회 학술대회 논문집
2017 .07
-
Circadian Lighting 개발을 위한 기초 연구
한국조명·전기설비학회 학술대회논문집
2015 .11
-
Diversification of the molecular clockwork for tissue-specific function: insight from a novel Drosophila Clock mutant homologous to a mouse Clock allele
BMB Reports
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0