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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 69 - 79 (11page)
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Ca2+ release from intracellular stores and influx fromextracellular reservoir regulate a wide range of physiologicalfunctions including muscle contraction and rhythmic heartbeat.
One of the most ubiquitous pathways involved in controlledCa2+ influx into cells is store-operated Ca2+ entry (SOCE),which is activated by the reduction of Ca2+ concentration inthe lumen of endoplasmic or sarcoplasmic reticulum (ER/SR).
Although SOCE is pronounced in non-excitable cells, accumulatingevidences highlight its presence and important roles inskeletal muscle and heart. Recent discovery of STIM proteins asER/SR Ca2+ sensors and Orai proteins as Ca2+ channel poreforming unit expedited the mechanistic understanding of thispathway. This review focuses on current advances of SOCEcomponents, regulation and physiologic and pathophysiologicroles in muscles. The specific property and the dysfunction ofthis pathway in muscle diseases, and new directions for futureresearch in this rapidly growing field are discussed.
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참고문헌 (92)
참고문헌 신청
Hovnanian, A / 2007 / SERCA pumps and human diseases / Subcell. Biochem 45:337~363
MacLennan, D. H. / 1998 / Structure-function relationships in the Ca (2+)-binding and translocation domain of SERCA1: physiological correlates in Brody disease / Acta. Physiol. Scand 643:55~67
Periasamy, M. / 2007 / SERCA pump isoforms: their role in calcium transport and disease / Muscle. Nerve 35:430~442
Bannister, R. A. / 2009 / The skeletal L-type Ca (2+) current is a major contributor to excitation-coupled Ca (2+) entry / J. Gen. Physiol 133:79~91
Cherednichenko, G. / 2004 / Conformational activation of Ca2+ entry by depolarization of skeletal myotubes / Proc. Natl. Acad. Sci. U. S. A 101:15793~15798
MacLennan, D. H. / 1998 / Structure-function relationships in the Ca (2+)-binding and translocation domain of SERCA1: physiological correlates in Brody disease / Acta. Physiol. Scand 643:55~67
Periasamy, M. / 2007 / SERCA pump isoforms: their role in calcium transport and disease / Muscle. Nerve 35:430~442
Bannister, R. A. / 2009 / The skeletal L-type Ca (2+) current is a major contributor to excitation-coupled Ca (2+) entry / J. Gen. Physiol 133:79~91
Cherednichenko, G. / 2004 / Conformational activation of Ca2+ entry by depolarization of skeletal myotubes / Proc. Natl. Acad. Sci. U. S. A 101:15793~15798
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