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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 104 - 109 (6page)
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FAM176A (family with sequence similarity 176 member A) is anovel molecule related to programmed cell death. A decreasedexpression of FAM176A has been found in several types ofhuman tumors in including lung cancers. In the present study,we investigated the biological activities of FAM176A on thehuman non–small cell lung cancer cell line H1299 cells. Weconstructed a recombinant adenovirus 5-FAM176A vector(Ad5-FAM176A) and evaluated the expression and anti-tumoractivities in vitro. Cell viability analysis revealed that theadenovirus-mediated increase of FAM176A inhibited thegrowth of the tumor cells in a dose- and time-dependentmanner. This inhibitory effect was mediated by both autophagyand apoptosis that involved caspase activation. In addition, cellcycle analysis suggested that Ad5-FAM176A could induce cellcycle arrest at the G2/M phase, all of which suggested thatadenovirus-mediated FAM176A gene transfer might present anew therapeutic approach for lung cancer treatment.
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참고문헌 (16)
참고문헌 신청
?ury?, A / 2012 / Expression of cyclin B1 after induction of senescence and cell death in non-small cell lung carcinoma A549 cells / Folia. Histochem. Cytobiol 50 : 58 ~ 67
Chang, Y. / 2013 / Adenovirus vector-mediated expression of TMEM166 inhibits human cancer cell growth by autophagy and apoptosis in vitro and in vivo / Cancer Lett 328 : 126
Eisenberg-Lerner, A. / 2009 / Life and death partners: apoptosis, autophagy and the cross-talk between them / Cell Death. Differ 16 : 966 ~ 975
El-Deiry, W. S. / 2003 / The role of p53 in chemosensitivity and radiosensitivity / Oncogene 22 : 7486 ~ 7495
Jemal, A. / 2010 / Global patterns of cancer incidence and mortality rates and trends / Cancer Epidemiol. Biomarkers Prev 19 : 1893 ~ 1907
Chang, Y. / 2013 / Adenovirus vector-mediated expression of TMEM166 inhibits human cancer cell growth by autophagy and apoptosis in vitro and in vivo / Cancer Lett 328 : 126
Eisenberg-Lerner, A. / 2009 / Life and death partners: apoptosis, autophagy and the cross-talk between them / Cell Death. Differ 16 : 966 ~ 975
El-Deiry, W. S. / 2003 / The role of p53 in chemosensitivity and radiosensitivity / Oncogene 22 : 7486 ~ 7495
Jemal, A. / 2010 / Global patterns of cancer incidence and mortality rates and trends / Cancer Epidemiol. Biomarkers Prev 19 : 1893 ~ 1907
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