지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 582 - 587 (6page)
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초록· 키워드
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Adipocyte differentiation is a complex developmental process forming adipocytes from various precursor cells. The murine 3T3-L1 preadipocyte cell line has been most frequently used in the studies of adipocyte differentiation. Differentiation of 3T3-L1 preadipocytes includes a medium containing fetal bovine serum (FBS) with hormonal induction. In this study, we observed that differentiation medium containing adult bovine serum (ABS) instead of FBS did not support differentiation of preadipocytes. Impaired adipocyte differentiation was due to the presence of a serum protein factor in ABS that suppresses differentiation of preadipocytes. Using a proteomic analysis,alpha-2-macroglobulin and paraoxonase/arylesterase 1, which were previously shown to suppress differentiation of preadipocytes,were identified as anti-adipogenic proteins. Although their functional mechanisms have not yet been elucidated, the anti-adipogenic effects of these proteins are discussed.
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참고문헌 (23)
참고문헌 신청
Atha, D. H / 1981 / Mechanism of precipitation of proteins by polyethylene glycols. Analysis in terms of excluded volume / J. Biol. Chem 256 : 12108 ~ 12117
Bellei, E. / 2011 / High-abundance proteins depletion for serum proteomic analysis: concomitant removal of non-targeted proteins / Amino Acids 40 : 145 ~ 156
Bode, J. G. / 2012 / Hepatic acute phase proteins--regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-kappaB-dependent signaling / Eur. J.
Choi, K. L. / 2004 / Proteomic analysis of adipocyte differentiation: Evidence that alpha2 macroglobulin is involved in the adipose conversion of 3T3 L1 preadipocytes / Prote
Eckerson, H. W. / 1983 / The human serum paraoxonase/arylesterase polymorphism / Am. J. Hum. Genet 35 : 1126 ~ 1138
Bellei, E. / 2011 / High-abundance proteins depletion for serum proteomic analysis: concomitant removal of non-targeted proteins / Amino Acids 40 : 145 ~ 156
Bode, J. G. / 2012 / Hepatic acute phase proteins--regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-kappaB-dependent signaling / Eur. J.
Choi, K. L. / 2004 / Proteomic analysis of adipocyte differentiation: Evidence that alpha2 macroglobulin is involved in the adipose conversion of 3T3 L1 preadipocytes / Prote
Eckerson, H. W. / 1983 / The human serum paraoxonase/arylesterase polymorphism / Am. J. Hum. Genet 35 : 1126 ~ 1138
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