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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 588 - 593 (6page)
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Apoptosis, programmed cell death, is a process involved in the development and maintenance of cell homeostasis in multicellular organisms. It is typically accompanied by the activation of a class of cysteine proteases called caspases.
Apoptotic caspases are classified into the initiator caspases and the executioner caspases, according to the stage of their action in apoptotic processes. Although caspase-3, a typical executioner caspase, has been studied for its mechanism and substrates,little is known of caspase-6, one of the executioner caspases. To understand the biological functions of caspase-6,we performed proteomics analyses, to seek for novel caspase-6substrates, using recombinant caspase-6 and HepG2 extract.
Consequently, 34 different candidate proteins were identified,through 2-dimensional electrophoresis/MALDI-TOF analyses.
Of these identified proteins, 8 proteins were validated with in vitro and in vivo cleavage assay. Herein, we report that HAUSP, Kinesin5B, GEP100, SDCCAG3 and PARD3 are novel substrates for caspase-6 during apoptosis.
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참고문헌 (24)
참고문헌 신청
Allsopp, T. E. / 2000 / Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis / Cell Death Differ 7 : 984 ~ 993
Alnemri, E. S. / 1996 / Human ICE/CED-3 protease nomenclature / Cell 87 : 171 ~
Cowling, V. / 2002 / Caspase-6 is the direc
Crawford, E. D. / 2011 / Caspase substrates and cellular remodeling / Annu. Rev. Biochem 80 : 1055 ~ 1087
Ellis, R. E. / 1991 / Mechanisms and functions of cell death / Annu. Rev. Cell Biol 7 : 663 ~ 698
Alnemri, E. S. / 1996 / Human ICE/CED-3 protease nomenclature / Cell 87 : 171 ~
Cowling, V. / 2002 / Caspase-6 is the direc
Crawford, E. D. / 2011 / Caspase substrates and cellular remodeling / Annu. Rev. Biochem 80 : 1055 ~ 1087
Ellis, R. E. / 1991 / Mechanisms and functions of cell death / Annu. Rev. Cell Biol 7 : 663 ~ 698
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