지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 305 - 309 (5page)
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초록· 키워드
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The determination of relatedness between individuals in a family is crucial in analysis of common complex diseases. We present a method to infer close inter-familial relationships based on SNP genotyping data and provide the relationship coefficient of kinship in Korean families. We obtained blood samples from 43 Korean individuals in two families. SNP data was obtained using the Affymetrix Genome-wide Human SNP array 6.0 and the Illumina Human 1M-Duo chip. To measure the kinship coefficient with the SNP genotyping data, we considered all possible pairs of individuals in each family. The genetic distance between two individuals in a pair was determined using the allele sharing distance method. The results show that genetic distance is proportional to the kinship coefficient and that a close degree of kinship can be confirmed with SNP genotyping data. This study represents the first attempt to identify the genetic distance between very closely related individuals.
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등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Balani, S. K. / 2005 / Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and drug candidate selection / Curr. Top. Med. Chem 5 : 1033 ~ 1038
Barrett, J. C. / 2006 / Evaluating coverage of genome-wide association studies / Nat. Genet 38 : 659 ~ 662
Botstein, D. / 2003 / Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease / Nat. Genet 33 : 228 ~ 2
Budowle, B. / 2008 / Forensically relevant SNP classes / Biotechniques 44 : 603 ~ 610
Dankyu Yoon / 2012 / Replication of genome-wide association studies on asthma and allergic diseases in Korean adult population / BMB Reports 45 (5) : 305 ~ 310
Barrett, J. C. / 2006 / Evaluating coverage of genome-wide association studies / Nat. Genet 38 : 659 ~ 662
Botstein, D. / 2003 / Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease / Nat. Genet 33 : 228 ~ 2
Budowle, B. / 2008 / Forensically relevant SNP classes / Biotechniques 44 : 603 ~ 610
Dankyu Yoon / 2012 / Replication of genome-wide association studies on asthma and allergic diseases in Korean adult population / BMB Reports 45 (5) : 305 ~ 310
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