지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 328 - 333 (6page)
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초록· 키워드
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Many bioactive molecules like recombinant human bone morphogenetic protein 2 (rhBMP-2) have been developed for mineralized bone grafts, for which proper scaffolds are necessary to successfully apply the bioactive molecules. In this study, we tested the osteogenic efficacy of rhBMP-2 produced in-house in combination with gelatin sponge as the scaffold carrier in a rabbit radial defect model. The efficacy of the rhBMP-2 was determined by alkaline phosphatase activity assay of C2C12 cells. Two groups of ten rabbits each were treated with rhBMP-2/gelatin sponge, or gelatin sponge only.
At 4 weeks, rhBMP-2/gelatin sponge grafts showed more bone regeneration than gelatin sponge grafts, as determined by X-ray radiography, micro-computed tomography, and histological analyses. At 8 weeks, rhBMP-2/gelatin sponge grafts exerted much stronger osteogenic effects. The study demonstrates the improved osteogenic efficacy of the rhBMP-2/gelatin sponge grafts in a rabbit radial bone defect model acting as a bone-inductive material.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Allendorph, G. P. / 2011 / Designer TGFbeta superfamily ligands with diversified functionality / PLoS One 6 : e26402 ~
Bessho, K. / 2000 / Bone induction by Escherichia coli-derived recombinant human bone morphogenetic protein-2 compared with Chinese hamster ovary cell-derived recombinant hu
Bhakta, G. / 2012 / Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2 / Biomaterials 33 33 : 6113 ~ 6122
Evans, B. E. / 1977 / Local hemostatic agents / N. Y. J. Dent 47 : 109 ~ 114
Hasegawa, Y. / 2008 / Short-term effects of rhBMP-2-enhanced bone augmentation beyond the skeletal envelope within a titanium cap in rabbit calvarium / J. Periodontol 79 : 3
Bessho, K. / 2000 / Bone induction by Escherichia coli-derived recombinant human bone morphogenetic protein-2 compared with Chinese hamster ovary cell-derived recombinant hu
Bhakta, G. / 2012 / Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2 / Biomaterials 33 33 : 6113 ~ 6122
Evans, B. E. / 1977 / Local hemostatic agents / N. Y. J. Dent 47 : 109 ~ 114
Hasegawa, Y. / 2008 / Short-term effects of rhBMP-2-enhanced bone augmentation beyond the skeletal envelope within a titanium cap in rabbit calvarium / J. Periodontol 79 : 3
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