지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 677 - 685 (9page)
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초록· 키워드
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In the process of tumorigenesis, normal cells are remodeled to cancer cells and protein expression patterns are changed to those of tumor cells. A newly formed tumor microenvironment elicits the immune system and, as a result, a humoral immune response takes place. Although the tumor antigens are undetectable in sera at the early stage of tumorigenesis,the nature of an antibody amplification response to antigens makes tumor-associated autoantibodies as promising early biomarkers in cancer diagnosis. Moreover, the recent development of proteomic techniques that make neo-epitopes of tumor-associated autoantigens discovered concomitantly has opened a new area of ‘immuno-proteomics’, which presents tumor-associated autoantibody signatures and confers information to redefine the process of tumorigenesis. In this article, the strategies recently used to identify and validate serum autoantibodies are outlined and tumor-associated antigens suggested until now as diagnostic/prognostic biomarkers in various tumor types are reviewed. Also, the meaning of autoantibody signatures and their clinical utility in personalized medicine are discussed. [BMB Reports 2012;45(12): 677-685]
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참고문헌 (26)
참고문헌 신청
Anderson, K. S. / 2005 / The sentinel within: exploiting the immune system for cancer biomarkers / J. Proteome Res. 4 : 1123 ~ 1133
Baldwin, R. W. / 1966 / Tumour-specific immunity against spontaneous rat tumours / Int. J. Cancer 1 : 257 ~ 264
Caron, M. / 2007 / Cancer immunomics using autoantibody signaturesfor biomarker discovery / Mol. Cell Proteomics 6 : 1115 ~ 1122
Chaput, N. / 2008 / The Janus face of dendritic cells in cancer / Oncogene 27 : 5920 ~ 5931
Chen, Y. / 2007 / Autoantibodies to Ca2+ binding protein Calnuc is a potential marker in colon cancer detection / Int. J. Oncol. 30 : 1137 ~ 1144
Baldwin, R. W. / 1966 / Tumour-specific immunity against spontaneous rat tumours / Int. J. Cancer 1 : 257 ~ 264
Caron, M. / 2007 / Cancer immunomics using autoantibody signaturesfor biomarker discovery / Mol. Cell Proteomics 6 : 1115 ~ 1122
Chaput, N. / 2008 / The Janus face of dendritic cells in cancer / Oncogene 27 : 5920 ~ 5931
Chen, Y. / 2007 / Autoantibodies to Ca2+ binding protein Calnuc is a potential marker in colon cancer detection / Int. J. Oncol. 30 : 1137 ~ 1144
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