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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 719 - 723 (5page)
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A close association between the obesity hormone leptin and breast cancer progression has been suggested. The present study investigated the molecular mechanism for enhanced leptin expression in breast cancer cells and its functional significance in breast cancer aggressiveness. We examined whether leptin expression level is affected by the oncoprotein human epidermal growth factor receptor2 (HER2), which is overexpressed in ∼30% of breast tumors. Here, we report, for the first time, that HER2 induces transcriptional activation of leptin in MCF10A human breast epithelial cells. We also showed that p38 mitogen-activated protein kinase signaling was involved in leptin expression induced by HER2. We showed a crucial role of leptin in the invasiveness of HER2-MCF10A cells using an siRNA molecule targeting leptin.
Taken together, the results indicate a molecular link between HER2 and leptin, providing supporting evidence that leptin represents a target for breast cancer therapy. [BMB Reports 2012; 45(12): 719-723]
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참고문헌 (24)
참고문헌 신청
Cascio, S. / 2008 / Mechanism of leptin expression in breast cancer cells: role of hypoxia- inducible factor-1alpha / Oncogene 27 : 540 ~ 547
Cuenda, A. / 1995 / SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1 / FEBS Lett. 364 : 229 ~ 233
Gambino, Y. P. / 2010 / 17Beta-estradiol enhances leptin expression in human placental cells through genomic and nongenomic actions / Biol Reprod. 83 : 42 ~ 51
Gambino, Y. P. / 2012 / Regulation of leptin expression by 17beta-estradiol in human placental cells involves membrane associated estrogen receptor alpha / Biochim. Biophys.
Garofalo, C. / 2006 / Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli / Clin. Cancer
Cuenda, A. / 1995 / SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1 / FEBS Lett. 364 : 229 ~ 233
Gambino, Y. P. / 2010 / 17Beta-estradiol enhances leptin expression in human placental cells through genomic and nongenomic actions / Biol Reprod. 83 : 42 ~ 51
Gambino, Y. P. / 2012 / Regulation of leptin expression by 17beta-estradiol in human placental cells involves membrane associated estrogen receptor alpha / Biochim. Biophys.
Garofalo, C. / 2006 / Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli / Clin. Cancer
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