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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 147 - 152 (6page)
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초록· 키워드
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Small interfering RNA (siRNA) functions through pairing withspecific mRNA sequences and results in the mRNA’s degradation.
It is a potential therapeutic approach for many diseasescaused by altered gene expression. The delivery of siRNA isstill a major problem due to its rapid degradation in the circulation.
Various strategies have been proposed to help with thecellular uptake of siRNA and short or small hairpin RNA(shRNA). Here, we reviewed recently published data regardinglocal applications of siRNA. Compared with systemic deliverymethods, local delivery of siRNA/shRNA has many advantages,such as targeting the specific tissues or organs, mimickinga gene knockout effect, or developing certain diseasesmodels. The eye, brain, and tumor tissues are ‘hot’ target tissues/organs for local siRNA delivery. The siRNA can be deliveredlocally, in naked form, with chemical modifications, or informulations with viral or non-viral vectors, such as liposomesand nanoparticles. This review provides a comprehensiveoverview of RNAi local administration and potential future applicationsin clinical treatment.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Ahmed Z / 2011 / Ocular neuroprotection by siRNA targeting caspase-2 / Cell Death Dis 2 : e173 ~
Brock A / 2014 / Silencing HoxA1 by intraductal injection of siRNA lipidoid nanoparticles prevents mammary tumor progression in mice / Sci Transl Med 6 : 217ra2 ~
Chen M / 2012 / Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery / ACS Nano 6 : 4835 ~ 4844
Dassie JP / 2009 / Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors / Nat Biotechnol 27 : 839 ~ 849
DiFiglia M / 2007 / Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits / Proc Natl Acad Sci U S A 104 :
Brock A / 2014 / Silencing HoxA1 by intraductal injection of siRNA lipidoid nanoparticles prevents mammary tumor progression in mice / Sci Transl Med 6 : 217ra2 ~
Chen M / 2012 / Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery / ACS Nano 6 : 4835 ~ 4844
Dassie JP / 2009 / Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors / Nat Biotechnol 27 : 839 ~ 849
DiFiglia M / 2007 / Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits / Proc Natl Acad Sci U S A 104 :
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