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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 184 - 189 (6page)
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Src homology 2-containing protein tyrosine phosphatase 2(SHP-2) is known to protect neurons from neurodegenerationduring ischemia/reperfusion injury. We recently reported thatROS-mediated oxidative stress promotes phosphorylation ofendogenous SHP-2 in astrocytes and complex formation betweencaveolin-1 and SHP-2 in response to oxidative stress. Toexamine the region of SHP-2 participating in complex formationwith caveolin-1, we generated three deletion mutantconstructs and six point mutation constructs of SHP-2.
Compared with wild-type SHP-2, binding of the N-SH2 domaindeletion mutant of SHP-2 to p-caveolin-1 was reducedgreatly, using flow cytometric competitive binding assays andsurface plasmon resonance (SPR). Moreover, deletion of theN-SH2 domain of SHP-2 affected H2O2-mediated ERK phosphorylationand Src phosphorylation at Tyr 419 in primary astrocytes,suggesting that N-SH2 domain of SHP-2 is responsiblefor the binding of caveolin-1 and contributes to the regulationof Src phosphorylation and activation following ROS-inducedoxidative stress in brain astrocytes.
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참고문헌 (28)
참고문헌 신청
Poole AW / 2005 / A SHPing tale: perspectives on the regulation of SHP-1 and SHP-2 tyrosine phosphatases by the C-terminal tail / Cell Signal 17:1323~1332
Salmond RJ / 2006 / SHP2 forecast for the immune system: fog gradually clearing / Trends Immunol 27:154~160
You M / 1999 / Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway / Mol Cell Biol 19:2416~2424
Arnaud M / 2004 / Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2 / Biochem J 382:545~556
Cai T / 2002 / Gab1and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation / J Cell Biol 159:103~112
Salmond RJ / 2006 / SHP2 forecast for the immune system: fog gradually clearing / Trends Immunol 27:154~160
You M / 1999 / Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway / Mol Cell Biol 19:2416~2424
Arnaud M / 2004 / Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2 / Biochem J 382:545~556
Cai T / 2002 / Gab1and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation / J Cell Biol 159:103~112
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