지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 519 - 526 (8page)
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초록· 키워드
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Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic dopaminergic pathway.
Changes in DA signaling in mesolimbic neurotransmission are widely believed to modify reward-related behaviors and are therefore closely associated with drug addiction. Recent evidence now suggests that as with drug addiction, obesity with compulsive eating behaviors involves reward circuitry of the brain, particularly the circuitry involving dopaminergic neural substrates. Increasing amounts of data from human imaging studies, together with genetic analysis, have demonstrated that obese people and drug addicts tend to show altered expression of DA D2 receptors in specific brain areas,and that similar brain areas are activated by food-related and drug-related cues. This review focuses on the functions of the DA system, with specific focus on the physiological interpretation and the role of DA D2 receptor signaling in food addiction.
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참고문헌 (28)
참고문헌 신청
Baik, J. H. / 1995 / Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors / Nature 377 : 424 ~ 428
Beaulieu, J. M / 2011 / The physiology, signaling, and pharmacology of dopamine receptors / Pharmacol. Rev 63 : 182 ~ 217
Bjorklund, A / 2007 / Dopamine neuron systems in the brain: an update / Trends Neurosci 30 : 194 ~ 202
Bunzow, J. R. / 1988 / Cloning and expression of a rat D2 dopamine receptor cDNA / Nature 336 : 783 ~ 787
Dal Toso, R. / 1989 / The dopamine D2 receptor: two molecular forms generated by alternative splicing / EMBO J 8 : 4025 ~ 4034
Beaulieu, J. M / 2011 / The physiology, signaling, and pharmacology of dopamine receptors / Pharmacol. Rev 63 : 182 ~ 217
Bjorklund, A / 2007 / Dopamine neuron systems in the brain: an update / Trends Neurosci 30 : 194 ~ 202
Bunzow, J. R. / 1988 / Cloning and expression of a rat D2 dopamine receptor cDNA / Nature 336 : 783 ~ 787
Dal Toso, R. / 1989 / The dopamine D2 receptor: two molecular forms generated by alternative splicing / EMBO J 8 : 4025 ~ 4034
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