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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 561 - 566 (6page)
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We examined the ways in which fenobam could promote not only the transduction of PEP-1-FK506BP into cells and tissues but also the neuroprotective effect of PEP-1-FK506BP against ischemic damage. Fenobam strongly enhanced the protective effect of PEP-1-FK506BP against H2O2-induced toxicity and DNA fragmentation in C6 cells. In addition, combinational treatment of fenobam with PEP-1-FK506BP significantly inhibited the activation of Akt and MAPK induced by H2O2, compared to treatment with PEP-1-FK506BP alone. Interestingly, our results showed that fenobam significantly increased the transduction of PEP-1-FK506BP into both C6 cells and the hippocampus of gerbil brains.
Subsequently, a transient ischemic gerbil model study demonstrated that fenobam pretreatment led to the increased neuroprotection of PEP-1-FK506BP in the CA1 region of the hippocampus. Therefore, these results suggest that fenobam can be a useful agent to enhance the transduction of therapeutic PEP-1-fusion proteins into cells and tissues, thereby promoting their neuroprotective effects.
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참고문헌 (24)
참고문헌 신청
[학술지(정기간
Aghdasi, B. / 2001 / FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle / Proc. Natl. Acad. Sci. U. S. A 98 : 2425 ~ 2430
Anwyl, R. / 1999 / Metabotropic glutamate receptors: electrophysiological properties and role in plasticity / Brain Res. Rev 29 : 83 ~ 120
Brillantes, A. B. / 1994 / Stabilization of calcium release channel(ryanodine receptor)function by FK506-binding protein / Cell 77 : 513 ~ 523
Burke, R. E. / 2007 / Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: Two approaches with therapeutic potential in the treat
Aghdasi, B. / 2001 / FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle / Proc. Natl. Acad. Sci. U. S. A 98 : 2425 ~ 2430
Anwyl, R. / 1999 / Metabotropic glutamate receptors: electrophysiological properties and role in plasticity / Brain Res. Rev 29 : 83 ~ 120
Brillantes, A. B. / 1994 / Stabilization of calcium release channel(ryanodine receptor)function by FK506-binding protein / Cell 77 : 513 ~ 523
Burke, R. E. / 2007 / Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: Two approaches with therapeutic potential in the treat
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