지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 555 - 560 (6page)
이용수
초록· 키워드
오류제보하기
Acrolein is the most reactive aldehydic product of lipid peroxidation and is found to be elevated in the brain when oxidative stress is high. The effects of acrolein on the structure and function of human Cu,Zn-superoxide dismutase (SOD) were examined. When Cu,Zn-SOD was incubated with acrolein, the covalent crosslinking of the protein was increased, and the loss of enzymatic activity was increased in a dose-dependent manner.
Reactive oxygen species (ROS) scavengers and copper chelators inhibited the acrolein-mediated Cu,Zn-SOD modification and the formation of carbonyl compound. The present study shows that ROS may play a critical role in acrolein-induced Cu,Zn-SOD modification and inactivation. When Cu,Zn-SOD that has been exposed to acrolein was subsequently analyzed by amino acid analysis, serine, histidine, arginine, threonine and lysine residues were particularly sensitive. It is suggested that the modification and inactivation of Cu,Zn-SOD by acrolein could be produced by more oxidative cell environments.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Bray, R. C. / 1974 / Reduction and inactivation of superoxide dismutase by hydrogen peroxide / Biochem. J 139 : 43 ~ 48
Choi, S. Y. / 1999 / Hydrogen peroxide-mediated Cu,Zn-superoxide dismutase fragmentation: protection by carnosine, homocarnosine and anserine / Biochim. Biophys. Acta 1472 :
Chung, F. L. / 1984 / Formation of cyclic 1,N2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde / Cancer Res 44 : 990 ~ 995
Cornett, C. R. / 1998 / Imbalance of trace elements related to oxidative damage in Alzheimer’s disease brain / Neurotoxicology 19 : 339 ~ 346
Esterbauer, H. / 1991 / Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes / Free Radic. Biol. Med 11 : 81 ~ 128
Choi, S. Y. / 1999 / Hydrogen peroxide-mediated Cu,Zn-superoxide dismutase fragmentation: protection by carnosine, homocarnosine and anserine / Biochim. Biophys. Acta 1472 :
Chung, F. L. / 1984 / Formation of cyclic 1,N2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde / Cancer Res 44 : 990 ~ 995
Cornett, C. R. / 1998 / Imbalance of trace elements related to oxidative damage in Alzheimer’s disease brain / Neurotoxicology 19 : 339 ~ 346
Esterbauer, H. / 1991 / Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes / Free Radic. Biol. Med 11 : 81 ~ 128
이 논문의 저자 정보
최근 본 자료
댓글(0)
0