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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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- 2012.1
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Hsp90 is one of the most conserved molecular chaperones ubiquitously expressed in normal cells and over-expressed in cancer cells. A pool of Hsp90 was found in cancer mitochondria and the expression of the mitochondrial Hsp90 homolog,TRAP1, was also elevated in many cancers. The mitochondrial pool of chaperones plays important roles in regulating mitochondrial integrity, protecting against oxidative stress, and inhibiting cell death. Pharmacological inactivation of the chaperones induced mitochondrial dysfunction and concomitant cell death selectively in cancer cells, suggesting they can be target proteins for the development of cancer therapeutics.
Several drug candidates targeting TRAP1 and Hsp90 in the mitochondria have been developed and have shown strong cytotoxic activity in many cancers, but not in normal cells in vitro and in vivo. In this review, recent developments in the study of mitochondrial chaperones and the mitochondria-targeted chaperone inhibitors are discussed [BMB reports 2012; 45(1):1-6]
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참고문헌 (25)
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Bagatell, R. / 2004 / Altered Hsp90 function in cancer: a unique therapeutic opportunity / Mol. Cancer Ther. 3 : 1021 ~ 1030
Biamonte, M. A. / 2010 / Heat shock protein 90: inhibitors in clinical trials / J. Med. Chem. 53 : 3 ~ 17
Blagg, B. S. / 2006 / Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation / Med. Res. Rev. 26 : 310 ~
Chen, B. / 2005 / The HSP90 family of genes in the human genome: insights into their divergence and evolution / Genomics 86 : 627 ~ 637
Bagatell, R. / 2004 / Altered Hsp90 function in cancer: a unique therapeutic opportunity / Mol. Cancer Ther. 3 : 1021 ~ 1030
Biamonte, M. A. / 2010 / Heat shock protein 90: inhibitors in clinical trials / J. Med. Chem. 53 : 3 ~ 17
Blagg, B. S. / 2006 / Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation / Med. Res. Rev. 26 : 310 ~
Chen, B. / 2005 / The HSP90 family of genes in the human genome: insights into their divergence and evolution / Genomics 86 : 627 ~ 637
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