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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 765 - 771 (7page)
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Cancer treatment has been stratified by companion biomarker tests that serve to provide information on the genetic status of cancer patients and to identify patients who can be expected to respond to a given treatment. This stratification guarantees better efficiency and safety during treatment. Cancer patients, however, marginally benefit from the current companion biomarker-aided treatment regimens, presumably because companion biomarker tests are dependent solely on the mutation status of several genes status quo.
In the true sense of the term, “personalized medicine”, cancer patients are deemed to be identified individually by their molecular signatures, which are not necessarily confined to genetic mutations. Glycosylation is tremendously dynamic and shows alterations in cancer. Evidence is accumulating that aberrant glycosylation contributes to the development and progression of cancer,holding the promise for use of glycosylation status as a companion biomarker in cancer treatment. There are, however, several challenges derived from the lack of a reliable detection system for aberrant glycosylation, and a limited library of aberrant glycosylation.
The challenges should be addressed if glycosylation status is to be used as a companion biomarker in cancer treatment and contribute to the fulfillment of personalized medicine. [BMB reports 2011;44(12): 765-771]
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참고문헌 (25)
참고문헌 신청
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Baxter, E. J / 2005 / Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders / Lancet 365 : 1054 ~ 1061
Bos, J. L / 1985 / Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia / Nature 315 : 726 ~ 730
Capon, D. J / 1983 / Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations / Nature 304 : 507 ~ 513
Druker, B. J / 1996 / Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells / Nat. Med 2 : 561 ~ 566
Baxter, E. J / 2005 / Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders / Lancet 365 : 1054 ~ 1061
Bos, J. L / 1985 / Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia / Nature 315 : 726 ~ 730
Capon, D. J / 1983 / Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations / Nature 304 : 507 ~ 513
Druker, B. J / 1996 / Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells / Nat. Med 2 : 561 ~ 566
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