지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 787 - 792 (6page)
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초록· 키워드
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We investigated whether silk fibroin peptide derived from the silkworm, Bombyx mori, could inhibit inflammation and enhance the anti-inflammatory activity of Tat-superoxide dismutase (Tat-SOD), which was previously reported to effectively penetrate various cells and tissues and exert anti-oxidative activity in a mouse model of inflammation. Inflammation was induced by topical treatment of mouse ears with 12-O-tetradecanoylphorbol-13-acetate (TPA). Histological, Western blot, and reverse transcription-polymerase chain reaction data demonstrated that silk fibroin peptide or Tat-SOD alone could suppress elevated levels of cyclooxygenase-2, interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha induced by TPA. Moreover, silk fibroin peptide significantly enhanced the anti-inflammatory activity of Tat-SOD, although it had no influence on in vitro and in vivo transduction of Tat-SOD. Silk fibroin peptide exhibited anti-inflammatory activity in a mice model of inflammation. Therefore,silk fibroin peptide alone or in combination with Tat-SOD might be used as a therapeutic agent for various inflammatory diseases. [BMB reports 2011; 44(12): 787-792]
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참고문헌 (25)
참고문헌 신청
Baldwin, Jr, A. S / 2001 / Series introduction: The transcription factor NF-κB and human disease / J. Clin. Invest 107 : 3 ~ 6
Bickers, D. R / 2006 / Oxidative stress in the pathogenesis of skin disease / J. Invest. Dermatol 126 : 2565 ~ 2575
Choi, H. S / 2006 / PEP-1-SOD fusion protein efficiently protects against paraquat- induced dopaminergic neuron damage in a Parkinson disease mouse model / Free Radic. Biol.
Dietz, G. P / 2010 / Cell-penetrating peptide technology to deliver chaperones and associated factors in diseases and basic research / Curr. Pharm. Biotechol 11 : 167 ~ 174
Egbers, J. H / 2008 / Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis / Cancer Res 68 : 1443 ~ 1450
Bickers, D. R / 2006 / Oxidative stress in the pathogenesis of skin disease / J. Invest. Dermatol 126 : 2565 ~ 2575
Choi, H. S / 2006 / PEP-1-SOD fusion protein efficiently protects against paraquat- induced dopaminergic neuron damage in a Parkinson disease mouse model / Free Radic. Biol.
Dietz, G. P / 2010 / Cell-penetrating peptide technology to deliver chaperones and associated factors in diseases and basic research / Curr. Pharm. Biotechol 11 : 167 ~ 174
Egbers, J. H / 2008 / Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis / Cancer Res 68 : 1443 ~ 1450
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