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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 656 - 663 (8page)
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Amyloid precursor protein (APP), which is critically involved in the pathogenesis of Alzheimer's disease (AD), is cleaved by gamma/epsilon-secretase activity and results in the generation of different lengths of the APP Intracellular C-terminal Domain (AICD). In spite of its small size and short half-life, AICD has become the focus of studies on AD pathogenesis. Recently, it was demonstrated that AICD binds to different intracellular binding partners ('adaptor protein'), which regulate its stability and cellular localization. In terms of choice of adaptor protein,phosphorylation seems to play an important role. AICD and its various adaptor proteins are thought to take part in various cellular events, including regulation of gene transcription, apoptosis,calcium signaling, growth factor, and NF-κB pathway activation,as well as the production, trafficking, and processing of APP, and the modulation of cytoskeletal dynamics. This review discusses the possible roles of AICD in the pathogenesis of neurodegenerative diseases including AD.
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참고문헌 (22)
참고문헌 신청
/ 2009 / 2009 Alzheimer's disease facts and figures / Alzheimers Dement 5 : 234 ~ 270
Annaert, W. G. / 1999 / Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons / J. Cell Biol. 147 :
Chyung, J. H. / 2005 / Gammasecretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage / J. Biol. Chem. 280 : 43
Cupers, P. / 2001 / The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nucle
De Strooper, B. / 2000 / Proteolytic processing and cell biological functions of the amyloid precursor protein / J. Cell Sci. 113 (11) : 1857 ~ 1870
Annaert, W. G. / 1999 / Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons / J. Cell Biol. 147 :
Chyung, J. H. / 2005 / Gammasecretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage / J. Biol. Chem. 280 : 43
Cupers, P. / 2001 / The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nucle
De Strooper, B. / 2000 / Proteolytic processing and cell biological functions of the amyloid precursor protein / J. Cell Sci. 113 (11) : 1857 ~ 1870
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