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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 683 - 687 (5page)
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초록· 키워드
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Previous studies have shown that one of the primary causes of increased iron content in the brain may be the release of excess iron from intracellular iron storage molecules such as ferritin. Free iron generates ROS that cause oxidative cell damage. Carnosine and related compounds such as endogenous histidine dipetides have antioxidant activities. We have investigated the protective effects of carnosine and homocarnosine against oxidative damage of DNA induced by reaction of ferritin with H2O2. The results show that carnosine and homocarnosine prevented ferritin/H2O2-mediated DNA strand breakage. These compounds effectively inhibited ferritin/H2O2-mediated hydroxyl radical generation and decreased the mutagenicity of DNA induced by the ferritin/H2O2 reaction.
Our results suggest that carnosine and related compounds might have antioxidant effects on DNA under pathophysiological conditions leading to degenerative damage such as neurodegenerative disorders.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Aldini, G. / 2002 / Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction / Biochem. Biophys. Res. Commun. 298 : 69
Alhamdani, M. S. / 2007 / Antiglycation and antioxidant effect of carnosine against glucose degradation products in peritoneal mesothelial cells / Nephron. Clin. Pract. 107
Auroma, O. I. / 1989 / Carnosine, homocarnosine and anserine: could they act as antioxidants in vivo? / Biochem. J. 264 : 863 ~ 869
Behl, C. / 1994 / Hydrogen peroxide mediates amyloid beta protein toxicity / Cell 77 : 817 ~ 827
Boldyrev, A. / 2004 / Protection of neuronal cells aginst reactive oxygen species by carnosine and related compounds / Comp. Biochem. Physiol. 137 : 81 ~ 88
Alhamdani, M. S. / 2007 / Antiglycation and antioxidant effect of carnosine against glucose degradation products in peritoneal mesothelial cells / Nephron. Clin. Pract. 107
Auroma, O. I. / 1989 / Carnosine, homocarnosine and anserine: could they act as antioxidants in vivo? / Biochem. J. 264 : 863 ~ 869
Behl, C. / 1994 / Hydrogen peroxide mediates amyloid beta protein toxicity / Cell 77 : 817 ~ 827
Boldyrev, A. / 2004 / Protection of neuronal cells aginst reactive oxygen species by carnosine and related compounds / Comp. Biochem. Physiol. 137 : 81 ~ 88
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