지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 390 - 395 (6page)
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초록· 키워드
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Oleanolic acid (OA), a triterpenoid known for its anti-inflammatory and anti-cancer properties, is commonly present in several medicinal plants but its anticoagulant activities have not been studied. Here, the anticoagulant properties of OA were determined by monitoring activated partial thromboplastin time (aPTT),prothrombin time (PT), fibrin polymerization as well as cell-based thrombin and activated factor X (FXa) generation activities. Data showed OA prolonged aPTT and PT significantly and inhibited thrombin catalyzed fibrin polymerization. In addition, OA inhibited the activities of thrombin and FXa and inhibited the generation of thrombin or FXa in human endothelial cells. OA also inhibited TNF-α-induced tissue factor expression on human endothelial cells. In accordance with these anticoagulant activities, OA showed an anticoagulant effect in vivo. These results indicate that OA possesses antithrombotic activities and suggest that daily consumption of a herb containing OA may be preventing thrombosis in pathological states. [BMB Reports 2012; 45(7): 390-395]
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참고문헌 (24)
참고문헌 신청
Bae, J. S. / 2008 / Protease activated receptor1 (PAR-1) activation by thrombin is protective inhuman pulmonary artery endothelial cells if endothelialprotein C receptor is
Bae, J. S. / 2011 / Antithrombotic and profibrinolytic activities of phloroglucinol / Food Chem. Toxicol. 49 : 1572 ~ 1577
Cho, S. O. / 2009 / Aralia cordata Protects Against Amyloid beta Protein (25-35)-Induced Neurotoxicity in Cultured Neurons and Has Antidementia Activities in Mice / JOURNAL
Chong, A. Y. / 2003 / Assessment of endothelial damage and dysfunction: observations in relation to heart failure / QJM 96 : 253 ~ 267
Davie, E. W. / 1991 / The coagulation cascade: initiation, maintenance, and regulation / Biochemistry 30 : 10363 ~ 10370
Bae, J. S. / 2011 / Antithrombotic and profibrinolytic activities of phloroglucinol / Food Chem. Toxicol. 49 : 1572 ~ 1577
Cho, S. O. / 2009 / Aralia cordata Protects Against Amyloid beta Protein (25-35)-Induced Neurotoxicity in Cultured Neurons and Has Antidementia Activities in Mice / JOURNAL
Chong, A. Y. / 2003 / Assessment of endothelial damage and dysfunction: observations in relation to heart failure / QJM 96 : 253 ~ 267
Davie, E. W. / 1991 / The coagulation cascade: initiation, maintenance, and regulation / Biochemistry 30 : 10363 ~ 10370
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