지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 415 - 420 (6page)
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초록· 키워드
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Diabetes is a well-known independent risk factor for vascular disease. However, its underlying mechanism remains unclear.
It has been reported that increased influx of the hexosamine biosynthesis pathway (HBP) induces O-GlcNAcylation of proteins,leading to insulin resistance. In this study, we determined whether or not O-GlcNAc modification of proteins could increase vessel contraction. Using an endothelium-denuded aortic ring, we observed that glucosamine induced OGlcNAcylation of proteins and augmented vessel contraction stimulated by U46619, a thromboxane A2 agonist, via augmentation of the phosphorylation of MLC20, MYPT1(Thr855),and CPI17, but not phenylephrine. Pretreatment with OGT inhibitor significantly ameliorated glucosamine-induced vessel constriction. Glucosamine treatment also increased RhoA activity,which was also attenuated by OGT inhibitor. In conclusion,glucosamine, a product of glucose influx via the HBP in a diabetic state, increases vascular contraction, at least in part, through activation of the RhoA/Rho kinase pathway,which may be due to O-GlcNAcylation. [BMB reports 2011;44(6): 415-420]
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참고문헌 (23)
참고문헌 신청
Arias, E. B / 2005 / Relationship between protein O-linked glycosylation and insulin- stimulated glucose transport in rat skeletal muscle following calorie restriction or exp
Buse,M.G / 2006 / Hexosamines, insulin resistance, and the complications of diabetes: current status / Am. J. Physiol. Endocrinol. Metab 290 : E1 ~ E8
Einstein, F. H / 2008 / Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance / FASEB J 22 : 3450 ~ 3457
Eto, M / 1995 / A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization / J. Biochem 118 :
Hanover, J. A / 2010 / The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine / Biochim. Biophys. Acta 1800 : 80 ~ 95
Buse,M.G / 2006 / Hexosamines, insulin resistance, and the complications of diabetes: current status / Am. J. Physiol. Endocrinol. Metab 290 : E1 ~ E8
Einstein, F. H / 2008 / Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance / FASEB J 22 : 3450 ~ 3457
Eto, M / 1995 / A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization / J. Biochem 118 :
Hanover, J. A / 2010 / The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine / Biochim. Biophys. Acta 1800 : 80 ~ 95
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