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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 405 - 409 (5page)
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초록· 키워드
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The present study demonstrated that valproic acid (VPA) transcriptionally regulates human GM3 synthase (hST3Gal V),which catalyzes ganglioside GM3 biosynthesis in ARPE-19 human retinal pigment epithelial cells. For this, we characterized the promoter region of the hST3Gal V gene. Functional analysis of the 5’-flanking region of the hST3Gal V gene revealed that the -177 to -83 region functions as the VPA-inducible promoter and that the CREB/ATF binding site at -143 is crucial for VPA-induced expression of hST3Gal V in ARPE-19 cells. In addition,the transcriptional activity of hST3Gal V induced by VPA in ARPE-19 cells was inhibited by SP600125, a c-Jun N-terminal kinase (JNK) inhibitor. In summary, our results identified the core promoter region in the hST3Gal V promoter and for the first time demonstrated that ATF2 binding to the CREB/ATF binding site at -143 is essential for transcriptional activation of hST3Gal V in VPA-induced ARPE-19 cells. [BMB reports 2011; 44(6): 405-409]
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참고문헌 (15)
참고문헌 신청
Bektas, M / 2004 / Glycosphingolipids and cell death / Glycoconjugate J 20 : 39 ~ 47
Bhoumik, A / 2008 / ATF2: a transcription factor that elicits oncogenic or tumor suppressor activities / Cell Cycle 7 : 2341 ~ 2345
Blaheta, R. A / 2002 / Anti-tumor mechanisms of valproate: a novel role for an old drug / Med. Res. Rev 22 : 492 ~ 511
Blaheta, R. A / 2005 / Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies / Med. Res. Rev 25 : 383 ~ 397
Choi, H. J / 2003 / Transcriptional regulation of the human GM3 synthase (hST3Gal V) gene during monocytic differentiation of HL-60 cells / FEBS Lett 555 : 204 ~ 208
Bhoumik, A / 2008 / ATF2: a transcription factor that elicits oncogenic or tumor suppressor activities / Cell Cycle 7 : 2341 ~ 2345
Blaheta, R. A / 2002 / Anti-tumor mechanisms of valproate: a novel role for an old drug / Med. Res. Rev 22 : 492 ~ 511
Blaheta, R. A / 2005 / Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies / Med. Res. Rev 25 : 383 ~ 397
Choi, H. J / 2003 / Transcriptional regulation of the human GM3 synthase (hST3Gal V) gene during monocytic differentiation of HL-60 cells / FEBS Lett 555 : 204 ~ 208
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