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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 362 - 368 (7page)
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초록· 키워드
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Dermcidin is a human antibiotic peptide that is secreted by the sweat glands and has no homology to other known antimicrobial peptides. As an initial step toward understanding dermcidin’s mode of action at bacterial membranes, we used homonuclear and heteronuclear NMR to determine the conformation of the peptide in 50% trifluoroethanol solution. We found that dermcidin adopts a flexible amphipathic α-helical structure with a helix-hinge-helix motif, which is a common molecular fold among antimicrobial peptides. Spin-down assays of dermcidin and several related peptides revealed that the affinity with which dermcidin binds to bacterial-mimetic membranes is primarily dependent on its amphipathic α-helical structure and its length (＞30 residues); its negative net charge and acidic pI have little effect on binding. These findings suggest that the mode of action of dermcidin is similar to that of other membrane-targeting antimicrobial peptides, though the details of its antimicrobial action remain to be determined
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참고문헌 (26)
참고문헌 신청
Bulet, P. / 2004 / Anti-microbial peptides: from invertebrates to vertebrates / Immunol. Rev. 198 : 169 ~ 184
Christensen, B. / 1988 / Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes / Proc. Natl. Acad. Sci. U.S.A. : 5072 ~ 5076
Epand, R. M. / 1999 / Diversity of antimicrobial peptides and their mechanisms of action / Biochim. Biophys. Acta. 1462 : 11 ~ 28
Finlay, B. B. / 2004 / Can innate immunity be enhanced to treat microbial infections? / Nat. Rev. Microbiol. 2 : 497 ~ 504
Flad, T. / 2002 / Detection of dermcidin-derived peptides in sweat by Protein-Chip technology / J. Immunol. Methods. 270 : 53 ~ 62
Christensen, B. / 1988 / Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes / Proc. Natl. Acad. Sci. U.S.A. : 5072 ~ 5076
Epand, R. M. / 1999 / Diversity of antimicrobial peptides and their mechanisms of action / Biochim. Biophys. Acta. 1462 : 11 ~ 28
Finlay, B. B. / 2004 / Can innate immunity be enhanced to treat microbial infections? / Nat. Rev. Microbiol. 2 : 497 ~ 504
Flad, T. / 2002 / Detection of dermcidin-derived peptides in sweat by Protein-Chip technology / J. Immunol. Methods. 270 : 53 ~ 62
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