지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 669 - 673 (5page)
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Human methionine sulfoxide reductase B3A (hMsrB3A) is an endoplasmic reticulum (ER) reductase that catalyzes the stereospecific reduction of methionine-R-sulfoxide to methionine in proteins. In this work, we identified an antimicrobial peptide from hMsrB3A protein. The N-terminal ER-targeting signal peptide (amino acids 1-31) conferred an antimicrobial effect in Escherichia coli cells. Sequence and structural analyses showed that the overall positively charged ER signal peptide had an Argand Pro-rich region and a potential hydrophobic α-helical segment that contains 4 cysteine residues. The potential α-helical region was essential for the antimicrobial activity within E. coli cells. A synthetic peptide, comprised of 2-26 amino acids of the signal peptide, was effective at killing Gram-negative E. coli,Klebsiella pneumoniae, and Salmonella paratyphi, but had no bactericidal activity against Gram-positive Staphylococcus aureus. [BMB reports 2011; 44(10): 669-673]
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참고문헌 (16)
참고문헌 신청
Andreu, D / 1998 / Animal antimicrobial peptides: an overview / Biopolymers 47 : 415 ~ 433
Brogden,K.A / 2005 / Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria / Nat. Rev. Microbiol 3 : 238 ~ 250
Fedders, H / 2008 / An exceptional salt-tolerant antimicrobial peptide derived from a novel gene family of haemocytes of the marine invertebrate Ciona intestinalis / Biochem
Hyun Ho Jung / 2010 / Analysis of the solution structure of the human antibiotic peptide dermcidin and its interaction with phospholipid vesicles / BMB reports 43 (5) : 362 ~
Kawaguchi, A / 2010 / Functional analysis of an alpha-helical antimicrobial peptide derived from a novel mouse defensin-like gene / Biochem. Biophys. Res. Commun 398 : 778 ~
Brogden,K.A / 2005 / Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria / Nat. Rev. Microbiol 3 : 238 ~ 250
Fedders, H / 2008 / An exceptional salt-tolerant antimicrobial peptide derived from a novel gene family of haemocytes of the marine invertebrate Ciona intestinalis / Biochem
Hyun Ho Jung / 2010 / Analysis of the solution structure of the human antibiotic peptide dermcidin and its interaction with phospholipid vesicles / BMB reports 43 (5) : 362 ~
Kawaguchi, A / 2010 / Functional analysis of an alpha-helical antimicrobial peptide derived from a novel mouse defensin-like gene / Biochem. Biophys. Res. Commun 398 : 778 ~
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