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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 329 - 334 (6page)
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Many proteins with poor transduction efficiency were reported to be delivered to cells by fusion with protein transduction domains (PTDs). In this study, we investigated the effect of levosulpiride on the transduction of PEP-1 ribosomal protein S3(PEP-1-rpS3), and examined its influence on the stimulation of the therapeutic properties of PEP-1-rpS3. PEP-1-rpS3 transduction into HaCaT human keratinocytes and mouse skin was stimulated by levosulpiride in a manner that did not directly affect the cell viability. Following 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, levosulpiride alone was ineffective in reducing TPA-induced edema and in inhibiting the elevated productions of inflammatory mediators and cytokines, such as cyclooxygenase-2, inducible nitric oxide synthase, interleukin-6 and -1β, and tumor necrosis factor-α. Anti-inflammatory activity by PEP-1-rpS3 + levosulpiride was significantly more potent than by PEP-1-rpS3 alone. These results suggest that levosulpiride may be useful for enhancing the therapeutic effect of PEP-1-rpS3 against various inflammatory diseases. [BMB reports 2011; 44(5): 329-334]
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참고문헌 (25)
참고문헌 신청
Afaq, F / 2005 / Anthocyanin- and hydrolyzable tannin- rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice / Int
Ahn, E. H / 2010 / Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice / Toxicology 276 : 192 ~ 197
Bertolini, A / 2002 / Selective COX-2 inhibitors and dual acting anti-inflammatory drugs: critical remarks / Curr. Med. Chem 9 : 1033 ~ 1043
Carey, M. A / 2003 / Cyclooxygenase enzymes in allergic inflammation and asthma. Prostaglandins Leukot / Essent. Fatty Acids 69 : 157 ~ 162
Choi, S. H / 2006 / Human PEP-1-ribosomal protein S3 protects against UV-induced skin cell death / FEBS LETTERS 580 : 6755 ~ 6762
Ahn, E. H / 2010 / Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice / Toxicology 276 : 192 ~ 197
Bertolini, A / 2002 / Selective COX-2 inhibitors and dual acting anti-inflammatory drugs: critical remarks / Curr. Med. Chem 9 : 1033 ~ 1043
Carey, M. A / 2003 / Cyclooxygenase enzymes in allergic inflammation and asthma. Prostaglandins Leukot / Essent. Fatty Acids 69 : 157 ~ 162
Choi, S. H / 2006 / Human PEP-1-ribosomal protein S3 protects against UV-induced skin cell death / FEBS LETTERS 580 : 6755 ~ 6762
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