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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 432 - 437 (6page)
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LBH is a transcription factor as a candidate gene for CHD associated with partial trisomy 2p syndrome. To identify potential LBH-interacting partners, a yeast two-hybrid screen using LBH as a bait was performed with a human heart cDNA library.
One of the clones identified encodes αB-crystallin. Co-immunoprecipitation and GST pull-down assays showed that LBH interacts with αB-crystallin, which is further confirmed by mammalian two-hybrid assays. Co-localization analysis showed that in COS-7 cells, αB-crystallin that is cytoplasmic alone, accumulates partialy in the nucleus when co-transfected with LBH. Transient transfection assays indicated that overexpression of LBH or αB-crystallin reduced the transcriptional activities of p53 and p21, respectively, Overexpression of both αB-crystallin and LBH together resulted in a stronger repression of the transcriptional activities of p21 and p53. These results showed that the interaction of LBH and αB-crystallin may inhibit synergistically the transcriptional regulation of p53and p21.
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참고문헌 (23)
참고문헌 신청
Ai, J. P. / 2008 / A human homolog of mouse Lbh gene, hLBH, expresses in heart and activates SRE and AP-1 mediated MAPK signaling pathway / Mol. Biol. Rep. 35 : 178 ~ 179
Bennardini, F. / 1992 / alphaBCrystallin in cardiac tissue: association with actin and desmin filaments / Circ. Res. 71 : 288 ~ 294
Briegel, K. J. / 2001 / Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development / Dev. Biol. 233 : 291
Briegel, K. J. / 2005 / Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh / Development 132 : 3305 ~ 331
Dubin, R. A. / 1990 / Human αB-crystallin gene and preferential promoter function in lens / Genomics 7 : 594 ~ 601
Bennardini, F. / 1992 / alphaBCrystallin in cardiac tissue: association with actin and desmin filaments / Circ. Res. 71 : 288 ~ 294
Briegel, K. J. / 2001 / Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development / Dev. Biol. 233 : 291
Briegel, K. J. / 2005 / Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh / Development 132 : 3305 ~ 331
Dubin, R. A. / 1990 / Human αB-crystallin gene and preferential promoter function in lens / Genomics 7 : 594 ~ 601
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