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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 418 - 423 (6page)
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초록· 키워드
오류제보하기
Emergency granulopoiesis is a very important strategy to supply efficient neutrophil number in response to infection. However, molecular mechanism involved in this process remains unclear. Here, we found that administration of WKYMVm, an immune modulating peptide, to septic mice strongly increased neutrophil number through augmented emergency granulopoiesis. WKYMVm-induced emergency granulopoiesis was blocked not only by a formyl peptide receptor 2 (FPR2) antagonist (WRW4), but also by FPR2 deficiency. As progenitors of neutrophils, Lin−c-kit＋Sca-1− cells expressed FPR2. WKYMVm-induced emergency granulopoiesis was also blocked by a phospholipase C inhibitor (U-73122). These results suggest that WKYMVm can stimulate emergency granulopoiesis via FPR2 and phospholipase C enzymatic activity.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Smith JA / 1994 / Neutrophils, host defense, and inflammation: a double-edged sword / J Leukoc Biol 56:672~686
Kruger P / 2015 / Neutrophils: Between host defence, immune modulation, and tissue injury / PLoS Pathog 11:e1004651
DeCoursey TE / 2016 / The intimate and controversial relationship between voltage-gated proton channels and the phagocyte NADPH oxidase / Immunol Rev 273:194~218
Iwasaki H / 2007 / Myeloid lineage commitment from the hematopoietic stem cell / Immunity 22:726~740
Seita J / 2010 / Hematopoietic stem cell: self-renewal versus differentiation / Wiley Interdiscip Rev Syst Biol Med 2:640~653
Kruger P / 2015 / Neutrophils: Between host defence, immune modulation, and tissue injury / PLoS Pathog 11:e1004651
DeCoursey TE / 2016 / The intimate and controversial relationship between voltage-gated proton channels and the phagocyte NADPH oxidase / Immunol Rev 273:194~218
Iwasaki H / 2007 / Myeloid lineage commitment from the hematopoietic stem cell / Immunity 22:726~740
Seita J / 2010 / Hematopoietic stem cell: self-renewal versus differentiation / Wiley Interdiscip Rev Syst Biol Med 2:640~653
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