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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 274 - 279 (6page)
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Mitochondria are crucial organelles that generate cellular energy and metabolites. Recent studies indicate that mitochondria also regulate immunity. In this review, we discuss key roles of mitochondria in immunity against pathogen infection and underlying mechanisms, focusing on discoveries using Caenorhabditis elegans. Various mitochondrial processes, including mitochondrial surveillance mechanisms, mitochondrial unfolded protein response (UPRmt), mitophagy, and reactive oxygen species (ROS) production, contribute to immune responses and resistance of C. elegans against pathogens. Biological processes of C. elegans are usually conserved across phyla. Thus, understanding the mechanisms of mitochondria-mediated defense responses in C. elegans may provide insights into similar mechanisms in complex organisms, including mammals.
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참고문헌 (46)
참고문헌 신청
West AP / 2011 / Mitochondria in innate immune responses / Nat Rev Immunol 11:389~402
Mehta MM / 2017 / Mitochondrial control of immunity: beyond ATP / Nat Rev Immunol 17:608
Ewbank JJ / 2016 / Local and long-range activation of innate immunity by infection and damage in C. elegans / Curr Opin Immunol 38:1~7
Kim DH / 2015 / Signaling in the innate immune response / WormBook :1~51
Prasai K / 2017 / Regulation of mitochondrial structure and function by protein import: A current review / Pathophysiology 24:107~122
Mehta MM / 2017 / Mitochondrial control of immunity: beyond ATP / Nat Rev Immunol 17:608
Ewbank JJ / 2016 / Local and long-range activation of innate immunity by infection and damage in C. elegans / Curr Opin Immunol 38:1~7
Kim DH / 2015 / Signaling in the innate immune response / WormBook :1~51
Prasai K / 2017 / Regulation of mitochondrial structure and function by protein import: A current review / Pathophysiology 24:107~122
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