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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 629 - 634 (6page)
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Transmembrane and coiled-coil domain family 3 (TMCC3) has been reported to be expressed in the human brain; however, its function is still unknown. Here, we found that expression of TMCC3 is higher in human whole brain, testis and spinal cord compared to other human tissues. TMCC3 was expressed in mouse developing hind brain, lung, kidney and somites, with strongest expression in the mesenchyme of developing tongue.
By expression of recombinant TMCC3 and its deletion mutants, we found that TMCC3 proteins self-assemble to oligomerize.
Immunostaining and confocal microscopy data revealed that TMCC3 proteins are localized in endoplasmic reticulum through transmembrane domains. Based on immunoprecipitation and mass spectroscopy data, TMCC3 proteins associate with TMCC3 and 14-3-3 proteins. This supports the idea that TMCC3 proteins form oligomers and that 14-3-3 may be involved in the function of TMCC3. Taken together, these results may be useful for better understanding of uncharacterized function of TMCC3.
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참고문헌 (15)
참고문헌 신청
Michielse CB / 2006 / Refinement of the locus for hereditary congenital facial palsy on chromosome 3q21 in two unrelated families and screening of positional candidate genes / Eur J Hum Genet 14:1306~1312
Zhang C / 2014 / Transmembrane and coiled-coil domain family 1 is a novel protein of the endoplasmic reticulum / PLoS One 9:e85206
Hirosawa M / 1999 / Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain / DNA Res 6:329~336
Jørgensen JR / 2006 / Identification of novel genes regulated in the developing human ventral mesencephalon / Exp Neurol 198:427~437
Gerhard DS / 2004 / The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) / Genome Res 14:2121~2127
Zhang C / 2014 / Transmembrane and coiled-coil domain family 1 is a novel protein of the endoplasmic reticulum / PLoS One 9:e85206
Hirosawa M / 1999 / Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain / DNA Res 6:329~336
Jørgensen JR / 2006 / Identification of novel genes regulated in the developing human ventral mesencephalon / Exp Neurol 198:427~437
Gerhard DS / 2004 / The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) / Genome Res 14:2121~2127
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