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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 599 - 608 (10page)
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초록· 키워드
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Regeneration, a process of reconstitution of the entire tissue, occurs throughout life in the olfactory epithelium (OE).
Regeneration of OE consists of several stages: proliferation of progenitors, cell fate determination between neuronal and non-neuronal lineages, their differentiation and maturation.
How the differentiated cell types that comprise the OE are regenerated, is one of the central questions in olfactory developmental neurobiology. The past decade has witnessed considerable progress regarding the regulation of transcription factors (TFs) involved in the remarkable regenerative potential of OE. Here, we review current state of knowledge of the transcriptional regulatory networks that are powerful modulators of the acquisition and maintenance of developmental stages during regeneration in the OE. Advance in our understanding of regeneration will not only shed light on the basic principles of adult plasticity of cell identity, but may also lead to new approaches for using stem cells and reprogramming after injury or degenerative neurological diseases.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Bailey BJ / 1975 / Olfactory neuroblastoma. Management and prognosis / Arch Otolaryngol 101 : 1 ~ 5
Bodian D / 1941 / Experimental studies on intraneural spread of poliomyelitis virus / Bulletin of the Johns Hopkins Hospital 68 : 248 ~ 267
Cau E / 1997 / Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors / Development 124 : 1611 ~ 1621
Cau E / 2002 / Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage / Development 129 : 1871 ~ 1880
Doty RL / 2001 / Olfaction / Annu Rev Psychol 52 : 423 ~ 452
Bodian D / 1941 / Experimental studies on intraneural spread of poliomyelitis virus / Bulletin of the Johns Hopkins Hospital 68 : 248 ~ 267
Cau E / 1997 / Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors / Development 124 : 1611 ~ 1621
Cau E / 2002 / Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage / Development 129 : 1871 ~ 1880
Doty RL / 2001 / Olfaction / Annu Rev Psychol 52 : 423 ~ 452
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