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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 393 - 398 (6page)
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The role of Bax inhibitor-1 (BI-1) in the protective mechanismagainst apoptotic stimuli has been studied; however, as little isknown about its role in death receptor-mediated cell death,this study was designed to investigate the effect of BI-1 onFas-induced cell death, and the underlying mechanisms.
HT1080 adenocarcinoma cells were cultured in highconcentration of glucose media and transfected with vectoralone (Neo cells) or BI-1-vector (BI-1 cells), and treated withFas. In cell viability, apoptosis, and caspase-3 analyses, theBI-1 cells showed enhanced sensitivity to Fas. Fas significantlydecreased cytosolic pH in BI-1 cells, compared with Neo cells,and this decrease correlated with BI-1 oligomerization,mitochondrial Ca2+ accumulation, and significant inhibition ofsodium-hydrogen exchanger (NHE) activity. Compared withNeo cells, a single treatment of BI-1 cells with the NHEinhibitor EIPA or siRNA against NHE significantly increasedcell death, which suggests that the viability of BI-1 cells isaffected by the maintenance of intracellular pH homeostasisthrough NHE.
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참고문헌 (25)
참고문헌 신청
Grzmil, M. / 2006 / Expression and functional analysis of Bax inhibitor- 1 in human breast cancer cells / J. Pathol 208:340~349
Schmits, R. / 2002 / Analysis of the antibody repertoire of astrocytoma patients against antigens expressed by gliomas / Int. J. Cancer 98:73~77
Sano, R. / 2012 / Endoplasmic reticulum protein BI-1 regulates Ca(2)(+)-mediated bioenergetics to promote autophagy / Genes Dev 26:1041~1054
Boldin, M. P. / 1996 / Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death / Cell 85 : 803 ~ 815
Brunner, T. / 2003 / Fas (CD95/Apo-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology / Semin. Immunol 15 : 167 ~ 176
Schmits, R. / 2002 / Analysis of the antibody repertoire of astrocytoma patients against antigens expressed by gliomas / Int. J. Cancer 98:73~77
Sano, R. / 2012 / Endoplasmic reticulum protein BI-1 regulates Ca(2)(+)-mediated bioenergetics to promote autophagy / Genes Dev 26:1041~1054
Boldin, M. P. / 1996 / Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death / Cell 85 : 803 ~ 815
Brunner, T. / 2003 / Fas (CD95/Apo-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology / Semin. Immunol 15 : 167 ~ 176
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