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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 388 - 392 (5page)
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초록· 키워드
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Berberine, a type of isoquinoline alkaloid isolated fromChinese medicinal herbs, has been reported to have variouspharmacological activities. Studies have demonstrated thatberberine has beneficial effects on vascular remodeling andalleviates restenosis after vascular injury. However, itsmechanism of action on vascular smooth muscle cellmigration is not fully understood. We therefore investigatedthe effect of berberine on human aortic smooth muscle cell(HASMC) migration. Boyden chamber assay was performed toshow that berberine inhibited HASMC migration dosedependently.
Real-time PCR and Western blotting analysesshowed that levels of matrix metalloproteinase (MMP)-2,MMP-9, and urokinase-type plasminogen activator (u-PA) werereduced by berberine at both the mRNA and protein levels.
Western blotting assay further confirmed that activities ofc-Fos, c-Jun, and NF-κB were significantly attenuated. Theseresults suggest that berberine effectively inhibited HASMCmigration, possibly by down-regulating MMP-2, MMP-9, andu-PA; and interrupting AP-1 and NF-κB mediated signaling pathways.
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참고문헌 (29)
참고문헌 신청
Redmond, E. M. / 1999 / Effect of pulse pressure on vascular smooth muscle cell migration: the role of urokinase and matrix metalloproteinase / Thromb. Haemost 81:293~300
Bond, M. / 1998 / Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-κB / FEBS Lett 435:29~34
Zhang, H. -W. / 2009 / AP-1 inhibits expression of MMP-2/9 and its effects on rat smooth muscle cells / J. Surg. Res 157:e31~e37
Moon, S. -K. / 2004 / PTEN induces G1 cell cycle arrest and inhibits MMP-9 expression via the regulation of NF-κB and AP-1 in vascular smooth muscle cells / Arch. Biochem. Biophys 421:267~276
Suh, S. -J. / 2006 / Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on TNF-α-induced matrix metalloproteinase-9 production and HASMC migration via down-regulated NF-κB and AP-1 / Biochem. Pharmacol 72:1680~1689
Bond, M. / 1998 / Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-κB / FEBS Lett 435:29~34
Zhang, H. -W. / 2009 / AP-1 inhibits expression of MMP-2/9 and its effects on rat smooth muscle cells / J. Surg. Res 157:e31~e37
Moon, S. -K. / 2004 / PTEN induces G1 cell cycle arrest and inhibits MMP-9 expression via the regulation of NF-κB and AP-1 in vascular smooth muscle cells / Arch. Biochem. Biophys 421:267~276
Suh, S. -J. / 2006 / Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on TNF-α-induced matrix metalloproteinase-9 production and HASMC migration via down-regulated NF-κB and AP-1 / Biochem. Pharmacol 72:1680~1689
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