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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 280 - 285 (6page)
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초록· 키워드
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Cancer cells undergo uncontrolled proliferation, and aberrantmitochondrial alterations. Tumor necrosis factor receptorassociatedprotein 1 (TRAP1) is a mitochondrial heat shockprotein. TRAP1 mRNA is highly expressed in some cancer celllines and tumor tissues. However, the effects of its overexpressionon mitochondria are unclear. In this study, we assessedmitochondrial changes accompanying TRAP1 overexpression,in a mouse cell line, NIH/3T3. We found that overexpressionof TRAP1 leads to a series of mitochondrial aberrations,including increase in basal ROS levels, and decrease inmitochondrial biogenesis, together with a decrease in peroxisomeproliferator-activated receptor gamma coactivator-1α(PGC-1α) mRNA levels. We also observed increased extracellularsignal-regulated kinase (ERK) phosphorylation, andenhanced proliferation of TRAP1 overexpressing cells. Thisstudy suggests that overexpression of TRAP1 might be a criticallink between mitochondrial disturbances and carcinogenesis.
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참고문헌 (38)
참고문헌 신청
Vargas-Roig, L. M. / 1997 / Heat shock proteins and cell proliferation in human breast cancer biopsy samples / Cancer Detect. Prev 21:441~451
Bianchi, M. S. / 1995 / Mitochondrial DNA mutations in normal and tumor tissues from breast cancer patients / Cytogenet. Cell Genet 71:99~103
Polyak, K. / 1998 / Somatic mutations of the mitochondrial genome in human colorectal tumours / Nat. Genet 20:291~293
Luciakova, K. / 1992 / Increased steady-state levels of several mitochondrial and nuclear gene transcripts in rat hepatoma with a low content of mitochondria / Eur. J. Biochem 205:1187~1193
Heerdt, B. G. / 2006 / Growth properties of colonic tumor cells are a function of the intrinsic mitochondrial membrane potential / Cancer Res 66:1591~1596
Bianchi, M. S. / 1995 / Mitochondrial DNA mutations in normal and tumor tissues from breast cancer patients / Cytogenet. Cell Genet 71:99~103
Polyak, K. / 1998 / Somatic mutations of the mitochondrial genome in human colorectal tumours / Nat. Genet 20:291~293
Luciakova, K. / 1992 / Increased steady-state levels of several mitochondrial and nuclear gene transcripts in rat hepatoma with a low content of mitochondria / Eur. J. Biochem 205:1187~1193
Heerdt, B. G. / 2006 / Growth properties of colonic tumor cells are a function of the intrinsic mitochondrial membrane potential / Cancer Res 66:1591~1596
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