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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 165 - 170 (6page)
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초록· 키워드
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We report here that an ethanol extract of Tetracera scandens, a Vietnamese medicinal plant, has anti-HIV activity and possesses strong inhibitory activity against HIV-1 reverse transcriptase (RTase). Using a MT-4 cell-based assay, we found that the T. scandens extract inhibited effectively HIV virus replication with an IC50 value in the range of 2.0-2.5 μg/ml while the cellular toxicity value (CC50) was more than 40-50 μg/ml concentration, thus yielding a minimum specificity index of 20-fold. Moreover, the anti-HIV efficacy of the T. scandens extract was determined to be due, in part, to its potent inhibitory activity against HIV-1 RTase activity in vitro. The inhibitory activity against the RTase was further confirmed by probing viral cDNA production, an intermediate of viral reverse transcription,in virus-infected cells using quantitative DNA-PCR analysis. Thus, these results suggest that T. scandens can be a useful source for the isolation and development of new anti-HIV-1 inhibitor(s). [BMB reports 2012; 45(3): 165-170]
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참고문헌 (21)
참고문헌 신청
Adamson, C. S. / 2006 / In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (Bevirimat) / J. Virol. 80 : 10957 ~ 10971
Adamson, C. S. / 2009 / Impact of human immunodeficiency virus type 1 resistance to protease inhibitors on evolution of resistance to the maturation inhibitor bevirimat (PA-4
Blanco, J. L. / 2011 / HIV-1 integrase inhibitor resistance and its clinical implications / J. Infect. Dis. 203 : 1204 ~ 1214
Dierynck, I. / 2007 / Binding kinetics of darunavir to human immunodeficiency virus type 1 protease explain the potent antiviral activity and high genetic barrier / J. Virol.
Feng, J. Y. / 2009 / The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study / Retrovirol
Adamson, C. S. / 2009 / Impact of human immunodeficiency virus type 1 resistance to protease inhibitors on evolution of resistance to the maturation inhibitor bevirimat (PA-4
Blanco, J. L. / 2011 / HIV-1 integrase inhibitor resistance and its clinical implications / J. Infect. Dis. 203 : 1204 ~ 1214
Dierynck, I. / 2007 / Binding kinetics of darunavir to human immunodeficiency virus type 1 protease explain the potent antiviral activity and high genetic barrier / J. Virol.
Feng, J. Y. / 2009 / The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study / Retrovirol
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