지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 133 - 140 (8page)
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초록· 키워드
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Cancers claim millions of lives each year. Early detection that can enable a higher chance of cure is of paramount importance to cancer patients. However, diagnostic tools for many forms of tumors have been lacking. Over the last few years, studies of chimeric RNAs as biomarkers have emerged. Numerous reports using bioinformatics and screening methodologies have described more than 30,000 expressed sequence tags (EST) or cDNA sequences as putative chimeric RNAs. While cancer cells have been well known to contain fusion genes derived from chromosomal translocations, rearrangements or deletions, recent studies suggest that trans-splicing in cells may be another source of chimeric RNA production. Unlike cis-splicing, trans-splicing takes place between two pre-mRNA molecules, which are in most cases derived from two different genes, generating a chimeric non-co-linear RNA. It is possible that trans-splicing occurs in normal cells at high frequencies but the resulting chimeric RNAs exist only at low levels. However the levels of certain RNA chimeras may be elevated in cancers, leading to the formation of fusion genes. In light of the fact that chimeric RNAs have been shown to be overrepresented in various tumors,studies of the mechanisms that produce chimeric RNAs and identification of signature RNA chimeras as biomarkers present an opportunity for the development of diagnoses for early tumor detection. (BMB reports 2012; 45(3): 133-140)
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참고문헌 (27)
참고문헌 신청
Akiva, P. / 2006 / Transcription- mediated gene fusion in the human genome / Genome Res. 16 : 30 ~ 36
Asmann, Y. W. / 2011 / A novel bioinformatics pipeline for identification and characterization of fusion transcripts in breast cancer and normal cell lines / Nucleic Acids Re
Birney, E. / 2007 / Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project / Nature 447 : 799 ~ 816
Coady, T. H. / 2010 / Trans-splicing- mediated improvement in a severe mouse model of spinal muscular atrophy / J. Neurosci. 30 : 126 ~ 130
Communi, D. / 2001 / Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes / J. Biol. Chem. 276 : 16561 ~ 16566
Asmann, Y. W. / 2011 / A novel bioinformatics pipeline for identification and characterization of fusion transcripts in breast cancer and normal cell lines / Nucleic Acids Re
Birney, E. / 2007 / Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project / Nature 447 : 799 ~ 816
Coady, T. H. / 2010 / Trans-splicing- mediated improvement in a severe mouse model of spinal muscular atrophy / J. Neurosci. 30 : 126 ~ 130
Communi, D. / 2001 / Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes / J. Biol. Chem. 276 : 16561 ~ 16566
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