지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 553 - 557 (5page)
이용수
초록· 키워드
오류제보하기
We previously reported that CDK2/Cyclin A can phosphorylate and activate the transcription factor NF-Y. In this study,we investigated a potential regulatory role for NF-Y in the transcription of Cyclin A and other cell cycle regulatory genes.
Gel-shift assays demonstrate that NF-Y binds to CCAAT sequences in the Cyclin A promoter, as well as to those in the promoters of cell cycle G2 regulators such as CDC2, Cyclin B and CDC25C. Furthermore, expression of Cyclin A increases NF-Y’s affinity for CCAAT sequences in the CDC2 promoter;however, Cyclin A’s induction of CDC2 transcription is antagonized by p21, an inhibitor of CDK2/Cyclin A. These results suggest a model wherein NF-Y binds to and activates transcription from the Cyclin A promoter, increasing cellular levels of Cyclin A/CDK2 and potentiating NF-Y’s capacity for transcriptional transactivation, and imply a positive feedback loop between NF-Y and Cyclin A/CDK2. Our findings are additionally indicative of a role for Cyclin A in activating Cyclin B/CDK1 through promoting NF-Y dependent transcription of Cyclin B and CDC2; NF-Y mediated crosstalk may therefore help to orchestrate cell-cycle progression. [BMB reports 2011;44(8): 553-557]
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Agarwal, M. L / 1995 / p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts / Proc. Natl. Acad. Sci. U.S.A
Bunz, F / 1998 / Requirement for p53 and p21 to sustain G2 arrest after DNA damage / Science 282 : 1497 ~ 1501
Chae, H. D / 2004 / Cdk2- dependent phosphorylation of the NF-Y transcription factor is essential for the expression of the cell cycle-regulatory genes and cell cycle G1/S a
Currie, R. A / 1998 / Biochemical characterization of the NF-Y transcription factor complex during B lymphocyte development / J. Biol. Chem 273 : 18220 ~ 18229
Dorn, A / 1987 / A multiplicity of CCAAT box-binding proteins / Cell 50 : 863 ~ 872
Bunz, F / 1998 / Requirement for p53 and p21 to sustain G2 arrest after DNA damage / Science 282 : 1497 ~ 1501
Chae, H. D / 2004 / Cdk2- dependent phosphorylation of the NF-Y transcription factor is essential for the expression of the cell cycle-regulatory genes and cell cycle G1/S a
Currie, R. A / 1998 / Biochemical characterization of the NF-Y transcription factor complex during B lymphocyte development / J. Biol. Chem 273 : 18220 ~ 18229
Dorn, A / 1987 / A multiplicity of CCAAT box-binding proteins / Cell 50 : 863 ~ 872
이 논문의 저자 정보
최근 본 자료
댓글(0)
0