지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 530 - 534 (5page)
이용수
초록· 키워드
오류제보하기
Cytochrome P450 (CYP) 1A2 gene polymorphisms are thought to be involved in the metabolism of theophylline (TP). We aimed to investigate the effect of CYP1A2*1C, CYP1A2*1D,CYP1A2*1E, and CYP1A2*1F polymorphisms of the CYP1A2on TP metabolism by PCR-RFLP in 100 Turkish patients with chronic obstructive pulmonary disease (COPD) receiving TP.
One hundred and one healthy volunteers were included as control group. The genotype frequencies of the CYP1A2*1D and CYP1A2*1F were found to be significantly different in the patients compared to the controls. The “T” allele at -2467 delT and the “C” allele at -163 C ＞ A in the CYP1A2 displayed association with a significantly increased risk for COPD. “T” allele at -2467 delT was also associated with a high risk of disease severity in COPD. In conclusion, our data suggest that genetic alterations in CYP1A2 may play a role both in the pharmacogenetics of TP and in the development of COPD.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
/ / http://www.cypalleles.ki.se/cyp1a2.htm.
/ / http://www.goldcopd.org
Aklillu, E. / 2003 / Genetic polymorphism of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphis
Allorge, D. / 2003 / Identification of a novel splice-site mutation in the CYP1A2 gene / Br. J. Clin. Pharmacol. 56 : 341 ~ 344
Arif, E. / 2007 / Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease / Clin. Chim. Acta. 382 : 37 ~ 42
Allorge, D. / 2003 / Identification of a novel splice-site mutation in the CYP1A2 gene / Br. J. Clin. Pharmacol. 56 : 341 ~ 344
Arif, E. / 2007 / Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease / Clin. Chim. Acta. 382 : 37 ~ 42
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Production of ω-Hydroxy Fatty Acid by Using CYP153s with High Concentration of Substrate
한국생물공학회 학술대회
2014 .10
-
Cloning, Expression, and Characterization of CYP102G4 from Streptomyces cattleya
한국생물공학회 학술대회
2017 .04
-
Characterization of two CYP153s from Bacteria and production of ω-hydroxy fatty acids
한국생물공학회 학술대회
2014 .04
-
Hypoxic repression of CYP7A1 through a HIF-1α- and SHP-independent mechanism
BMB Reports
2016 .01
-
CYP 효소의 multi-step cascade 반응 및 전망
BT NEWS
2019 .04
-
Production of ω-hydroxy palmitic acid using CYP153A and comparison of cytochrome P450 electron transfer system in vivo
한국생물공학회 학술대회
2016 .04
-
Highly Efficient and Regioselective C-H Hydroxylation of OmeprazoleSulfide by CYP102A1 Mutants
한국생물공학회 학술대회
2016 .04
-
Evolution of CYP102D1 from Streptomyces avermitilis to Increase Hydroxylation Activity towards Kaempferol
한국생물공학회 학술대회
2012 .04
-
Enhancing the Catalytic Activity of CYP102D1 for Daidzein Regioselective Hydroxylation by Engineering in both Heme and Reductase Domain
한국생물공학회 학술대회
2013 .10
-
Application of Bacterial CYP102A1 Mutants as a Tool for the Generation of Human Drug Metabolites
한국생물공학회 학술대회
2011 .10
-
Regioselectivity-driven evolution of CYP102D1 for improved synthesis of 3′-ortho-dihydroxyisoflavone
한국생물공학회 학술대회
2015 .04
-
Inhibition of Ethanol-induced CYP2E1 by Curcuma longa L. Extract
한국생물공학회 학술대회
2009 .10
-
Regioselective Hydroxylation of 17β-estradiol by CYP102A1 Mutants
한국생물공학회 학술대회
2014 .10
-
Functional Characterization of Steroid Hydroxylase CYP106A1 Derived from Bacillus megaterium
한국생물공학회 학술대회
2014 .10
-
Functional Characterization of Versatile Cytochrome P450 Monoxygenease from the CYP Gene Library of filamentous fungus Fusarium oxysporum.
한국생물공학회 학술대회
2013 .10
-
Gene expressions of the Dhb, Vtg, Arnt, CYP4 and CYP314 in Daphnia magna by toxicity of glyphosate and methidathion
한국생물공학회 학술대회
2011 .04
-
Substrate specificity of mutated cytochrome P450 (CYP102A5) from Bacillus cereus ATCC14579
한국생물공학회 학술대회
2007 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0