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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 256 - 265 (10page)
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초록· 키워드
오류제보하기
Cardiovascular and neurodegenerative diseases are major health threats in many developed countries. Recently, target tissues derived from human embryonic stem (hES) cells and induced pluripotent stem cells (iPSCs), such as cardiomyocytes (CMs) or neurons, have been actively mobilized for drug screening. Knowledge of drug toxicity and efficacy obtained using stem cell-derived tissues could parallel that obtained from human trials. Furthermore, iPSC disease models could be advantageous in the development of personalized medicine in various parts of disease sectors. To obtain the maximum benefit from iPSCs in disease modeling, researchers are now focusing on aging, maturation, and metabolism to recapitulate the pathological features seen in patients. Compared to pediatric disease modeling, adult-onset disease modeling with iPSCs requires proper maturation for full manifestation of pathological features. Herein, the success of iPSC technology, focusing on patient-specific drug treatment, maturation-based disease modeling, and alternative approaches to compensate for the current limitations of patient iPSC modeling, will be further discussed.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Ban H / 2011 / Efficient generation of transgene-free human induced pluripotent stem cells(iPSCs)by temperature-sensitive Sendai virus vectors / Proc Natl Acad Sci U S A 108 : 1423
Carvajal-Vergara X / 2010 / Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome / Nature 465 : 808 ~ 812
Filipczyk AA / 2007 / Regulation of cardiomyocyte differentiation of embryonic stem cells by extracellular signalling / Cell Mol Life Sci 64 : 704 ~ 718
Itzhaki I / 2011 / Modelling the long QT syndrome with induced pluripotent stem cells / Nature 471 : 225 ~ 229
Kim C / 2010 / Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation / Stem Cells Dev 1
Carvajal-Vergara X / 2010 / Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome / Nature 465 : 808 ~ 812
Filipczyk AA / 2007 / Regulation of cardiomyocyte differentiation of embryonic stem cells by extracellular signalling / Cell Mol Life Sci 64 : 704 ~ 718
Itzhaki I / 2011 / Modelling the long QT syndrome with induced pluripotent stem cells / Nature 471 : 225 ~ 229
Kim C / 2010 / Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation / Stem Cells Dev 1
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