지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 581 - 586 (6page)
이용수
초록· 키워드
오류제보하기
Epidermal growth factor (EGF) is known to play key roles inskin regeneration and wound-healing. Here, we demonstratethat Pep2-YAC, a tripeptide covering residues 29-31 in the Bloop of EGF, promotes the proliferation of HaCaT keratinocyteswith activity comparable to EGF. The treatment of HaCaT cellswith Pep2-YAC induced phosphorylation, internalization, anddegradation of EGFR and organization of signaling complexes,which consist of Grb2, Gab1, SHP2, and PI3K. In addition, itstimulated the phosphorylation of ERK1/2 at Thr 202/Tyr 204and of Akt1 at Ser 473 and the nuclear translocation of EGFR,STAT3, c-Jun, and c-Fos. These results suggest that Pep2-YACmay be useful as a therapeutic agent for skin regeneration andwound-healing as an EGFR agonist.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bancroft, C. C. / 2002 / Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-κB and AP-1 activation and IL-8 and VEG
Chan, K. S. / 2004 / Epidermal growth factor receptor- mediated activation of Stat3 during multistage skin carcinogenesis / Cancer Res 64 : 2382 ~ 2389
Ching, Y. H. / 2011 / The use of growth factors and other humoral agents to accelerate and enhance burn wound healing / Eplasty 11 : e41 ~
Doma, E. / 2013 / EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers / Int. J. Mol. Sci
Dreux, A. C. / 2006 / The epidermal growth factor receptors and their family of ligands: Their putative role in atherogenesis / Atherosclerosis 186 : 38 ~ 53
Chan, K. S. / 2004 / Epidermal growth factor receptor- mediated activation of Stat3 during multistage skin carcinogenesis / Cancer Res 64 : 2382 ~ 2389
Ching, Y. H. / 2011 / The use of growth factors and other humoral agents to accelerate and enhance burn wound healing / Eplasty 11 : e41 ~
Doma, E. / 2013 / EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers / Int. J. Mol. Sci
Dreux, A. C. / 2006 / The epidermal growth factor receptors and their family of ligands: Their putative role in atherogenesis / Atherosclerosis 186 : 38 ~ 53
이 논문의 저자 정보
최근 본 자료
댓글(0)
0