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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 558 - 562 (5page)
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OASL1 is a member of the 2’-5’-oligoadenylate synthetase(OAS) family and promotes viral clearance by activating RNaseL. OASL1 interacts with the 5’-untranslated region (UTR) ofinterferon regulatory factor 7 (Irf7) and inhibits its translation.
To identify the secondary structure required for OASL1binding, we examined the 5’-UTR of the Irf7 transcript using“selective 2’-hydroxyl acylation analyzed by primer extension”(SHAPE). SHAPE takes advantage of the selective acylation ofresidues in single-stranded regions by 1-methyl-7-nitroisatoicanhydride (1M7). We found five major acylation sites locatedin, or next to, predicted single-stranded regions of the Irf75’-UTR. These results demonstrate the involvement of the stemstructure of the Irf7 5’-UTR in the regulation of Irf7 translation,mediated by OASL1.
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참고문헌 (21)
참고문헌 신청
Akira, S. / 2006 / Pathogen recognition and innate immunity / Cell 124 : 783 ~ 801
Bevilacqua, A. / 2003 / Post-transcriptional regulation of gene expression by degradation of messenger RNAs / J. Cell. Physiol 195 : 356 ~ 372
Deigan, K. E. / 2009 / Accurate SHAPE-directed RNA structure determination / Proc. Natl. Acad. Sci. U. S. A 106 : 97 ~ 102
Gherghe, C. M. / 2008 / Strong correlation between SHAPE chemistry and the generalized NMR order parameter (S2) in RNA / J. Am. Chem. Soc 130 : 12244 ~ 12245
Honda, K. / 2005 / IRF-7 is the master regulator of type-I interferon-dependent immune responses / Nature 434 : 772 ~ 777
Bevilacqua, A. / 2003 / Post-transcriptional regulation of gene expression by degradation of messenger RNAs / J. Cell. Physiol 195 : 356 ~ 372
Deigan, K. E. / 2009 / Accurate SHAPE-directed RNA structure determination / Proc. Natl. Acad. Sci. U. S. A 106 : 97 ~ 102
Gherghe, C. M. / 2008 / Strong correlation between SHAPE chemistry and the generalized NMR order parameter (S2) in RNA / J. Am. Chem. Soc 130 : 12244 ~ 12245
Honda, K. / 2005 / IRF-7 is the master regulator of type-I interferon-dependent immune responses / Nature 434 : 772 ~ 777
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