지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 424 - 432 (9page)
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The defining feature of Parkinson’s disease is a progressive andselective demise of dopaminergic neurons. A recent report onParkinson’s disease animal model demonstrates that poly(ADP-ribose) (PAR) dependent cell death, also namedparthanatos, is accountable for selective dopaminergic neuronalloss. Parthanatos is a programmed necrotic cell death,characterized by PARP1 activation, apoptosis inducing factor(AIF) nuclear translocation, and large scale DNA fragmentation.
Besides cell death regulation via interaction with AIF, PARmolecule mediates diverse cellular processes including genomicstability, cell division, transcription, epigenetic regulation, andstress granule formation. In this review, we will discuss the rolesof PARP1 activation and PAR molecules in the pathologicalprocesses of Parkinson’s disease. Potential interaction betweenPAR molecule and Parkinson’s disease protein interactome arebriefly introduced. Finally, we suggest promising points oftherapeutic intervention in the pathological PAR signalingcascade to halt progression in Parkinson’s disease.
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참고문헌 (26)
참고문헌 신청
[학술지
Andrabi, S. A. / 2008 / Mitochondrial and nuclear cross talk in cell death: parthanatos / Ann. N. Y. Acad. Sci 1147 : 233 ~ 241
Burkle, A. / 2005 / Poly(ADP-ribose). The most elaborate metabolite of NAD+ / FEBS J 272 : 4576 ~ 4589
Cortes, U. / 2004 / Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice / Mol. Cell Bi
Fatokun, A. A. / 2014 / Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities / Br. J. Pharmacol 171 : 2000 ~ 2016
Andrabi, S. A. / 2008 / Mitochondrial and nuclear cross talk in cell death: parthanatos / Ann. N. Y. Acad. Sci 1147 : 233 ~ 241
Burkle, A. / 2005 / Poly(ADP-ribose). The most elaborate metabolite of NAD+ / FEBS J 272 : 4576 ~ 4589
Cortes, U. / 2004 / Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice / Mol. Cell Bi
Fatokun, A. A. / 2014 / Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities / Br. J. Pharmacol 171 : 2000 ~ 2016
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