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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 433 - 438 (6page)
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초록· 키워드
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Plant sterols have shown potent anti-proliferative effects andapoptosis induction against breast and prostate cancers.
However, the effect of sterols against hepatic cancer has notbeen investigated. In the present study, we assessed whetherthe stigmasterol isolated from Navicula incerta possessesapoptosis inductive effect in hepatocarcimona (HepG2) cells.
According to the results, Stigmasterol has up-regulated theexpression of pro-apoptotic gene expressions (Bax, p53) whiledown-regulating the anti-apoptotic genes (Bcl-2). Probably viamitochondrial apoptosis signaling pathway. With the inductionof apoptosis caspase-8, 9 were activated. The DNAdamage and increase in apoptotic cell numbers were observedthrough Hoechst staining, annexin V staining and cell cycleanalysis. According to these results, we can suggest that thestigmasterol shows potent apoptosis inductive effects and hasthe potential to be tested as an anti-cancer therapeutic againstliver cancer.
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참고문헌 (25)
참고문헌 신청
Caihong Zhou / 2013 / Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells / BMB Reports 46(2):113~118
Antonsson, B. / 2001 / Bax and other pro-apoptotic Bcl-2 family ‘‘killer-proteins” and their victim the mitochondrion / Cell Tissue Res 306 : 347 ~ 361
Awad, A. B. / 1996 / Beta-sitosterols inhibits HT-29 human colon cancer cell growth and alters membrane lipids / Anticancer Res 16 : 2797 ~ 2804
Awad, A. B. / 2000 / Phytosterols as anticancer dietary components: evidence and mechanism of action / J. Nutr 130 : 2127 ~ 2130
Deveraux, Q. L. / 1999 / IAP family proteins suppressors of apoptosis / Genes Dev 13 : 239 ~ 252
Antonsson, B. / 2001 / Bax and other pro-apoptotic Bcl-2 family ‘‘killer-proteins” and their victim the mitochondrion / Cell Tissue Res 306 : 347 ~ 361
Awad, A. B. / 1996 / Beta-sitosterols inhibits HT-29 human colon cancer cell growth and alters membrane lipids / Anticancer Res 16 : 2797 ~ 2804
Awad, A. B. / 2000 / Phytosterols as anticancer dietary components: evidence and mechanism of action / J. Nutr 130 : 2127 ~ 2130
Deveraux, Q. L. / 1999 / IAP family proteins suppressors of apoptosis / Genes Dev 13 : 239 ~ 252
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