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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 439 - 444 (6page)
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이 논문의 연구 히스토리 (3)
2014
AMD3100 Improves Ovariectomy-induced Osteoporosis in Mice by Facilitating Mobilization of Hematopoietic Stem/progenitor Cells
임진영
,
김남오
,
진희경
외 2명
한국실험동물학회 학술발표대회 논문집
2014.02
학술대회자료
AMD3100 improves ovariectomy-induced osteoporosis in mice by facilitating mobilization of hematopoietic stem/progenitor cells : AMD3100을 이용하여 골수조혈줄기세포 방출 촉진에 의한 난소절제로 유도된 골다공증 개선
임진영
의학과
2014.01
학위논문
AMD3100 improves ovariectomy-induced osteoporosis in mice by facilitating mobilization of hematopoietic stem/progenitor cells
임진영
,
민우기
,
박민희
외 6명
BMB Reports
2014.01
학술저널
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초록· 키워드
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Inhibition of an increase of osteoclasts has become the mostimportant treatment for osteoporosis. The CXCR4 antagonist,AMD3100, plays an important role in the mobilization ofosteoclast precursors within bone marrow (BM). However, theactual therapeutic impact of AMD3100 in osteoporosis has notyet been ascertained. Here we demonstrate the therapeuticeffect of AMD3100 in the treatment of ovariectomy-inducedosteoporosis in mice. We found that treatment with AMD3100resulted in direct induction of release of SDF-1 from BM toblood and mobilization of hematopoietic stem/progenitor cells(HSPCs) in an osteoporosis model. AMD3100 prevented bonedensity loss after ovariectomy by mobilization of HSPCs,suggesting a therapeutic strategy to reduce the number ofosteoclasts on bone surfaces. These findings support thehypothesis that treatment with AMD3100 can result in efficientmobilization of HSPCs into blood through direct blockade ofthe SDF-1/CXCR4 interaction in BM and can be considered as a potential new therapeutic intervention for osteoporosis.
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참고문헌 (19)
참고문헌 신청
Christopher, M. J. / 2008 / Granulocyte colony- stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation / J. Bone. Miner. Res 23 : 1765 ~ 177
Dale, D. C. / 2003 / Severe chronic neutropenia: treatment and follow-up of patients in the severe chronic neutropenia international registry / Am. J. Hematol 72 : 82 ~ 93
Dar, A / 2011 / Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells / L
De Klerck, B. / 2005 / Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis / Arthritis. Res. Ther 7 : R1208 ~ 1220
Golan, K. / 2012 / S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release / Blood 119 : 2478 ~ 2488
Dale, D. C. / 2003 / Severe chronic neutropenia: treatment and follow-up of patients in the severe chronic neutropenia international registry / Am. J. Hematol 72 : 82 ~ 93
Dar, A / 2011 / Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells / L
De Klerck, B. / 2005 / Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis / Arthritis. Res. Ther 7 : R1208 ~ 1220
Golan, K. / 2012 / S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release / Blood 119 : 2478 ~ 2488
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