지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 445 - 450 (6page)
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초록· 키워드
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Glucose regulated protein 78 (GRP78) is frequently highlyexpressed in tumor cells, contributing to the acquisition of severalphenotypic cancer hallmarks. GRP78 expression is also positivelycorrelated with tumor metastasis, and promotes hepatocellularcarcinoma cell invasion via increasing cell motility, however,other mechanisms involving the prometastatic roles of GRP78remain to be elucidated. Here we report that forced GRP78expression promotes colon cancer cell migration and invasionthrough upregulating MMP-2, MMP-9 and especially uPAproduction. These effects of GRP78 are mediated by enhancingthe activation of β-catenin signaling. Interestingly, we identify thatGRP78 interacts with uPA both in the cells and in the culturemedium, suggesting that GRP78 protein is likely to directlyfacilitate uPA secretion via protein-protein interaction. Takentogether, our findings demonstrate for the first time that besidesstimulation of cell motility, GRP78 can act by increasingproteases production to promote tumor cell invasion.
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참고문헌 (20)
참고문헌 신청
Agarwal, A. / 2005 / The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor- kappa B and beta-cate
Blasi, F. / 2002 / uPAR: a versatile signalling orchestrator / Nat. Rev. Mol. Cell Biol 3 : 932 ~ 943
Chiu, C. C. / 2008 / Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervent
Davidson, D. J. / 2005 / Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78 / Cancer Res
Fu, Y. / 2006 / Glucose regulated proteins in cancer progression, drug resistance and immunotherapy / Cancer Biol. Ther 5 : 741 ~ 744
Blasi, F. / 2002 / uPAR: a versatile signalling orchestrator / Nat. Rev. Mol. Cell Biol 3 : 932 ~ 943
Chiu, C. C. / 2008 / Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervent
Davidson, D. J. / 2005 / Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78 / Cancer Res
Fu, Y. / 2006 / Glucose regulated proteins in cancer progression, drug resistance and immunotherapy / Cancer Biol. Ther 5 : 741 ~ 744
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