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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 653 - 658 (6page)
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After the outbreak of the swine-origin influenza A H1N1 virus in April 2009, World Health Organization declared this novel H1N1 virus as the first pandemic influenza virus (2009 pH1N1)of the 21st century. To elucidate the characteristics of 2009pH1N1, the growth properties of A/Korea/01/09 (K/09) was analyzed in cells. Interestingly, the maximal titer of K/09 was higher than that of a seasonal H1N1 virus isolated in Korea 2008 (S/08)though the RNP complex of K/09 was less competent than that of S/08. In addition, the NS1 protein of K/09 was determined as a weak interferon antagonist as compared to that of S/08. Thus, in order to confine genetic determinants of K/09, activities of two major surface glycoproteins were analyzed. Interestingly, K/09possesses highly reactive NA proteins and weak HA cell-binding avidity. These findings suggest that the surface glycoproteins might be a key factor in the features of 2009 pH1N1. [BMB Reports 2012; 45(11): 653-658]
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참고문헌 (24)
참고문헌 신청
[학술지(정기간행물
Abed, Y. / 2011 / The 2009 pandemic H1N1 D222G hemagglutinin mutation alters receptor specificity and increases virulence in mice but not in ferrets / J. Infect. Dis. 204 :
CDC / 2009 / Swine influenza A (H1N1) infection in two children-Southern California, March-April 2009 / MMWR. Morb. Mortal. Wkly. Rep. 58 : 400 ~ 402
Cheol-Min Ghim / 2010 / The art of reporter proteins in science: past, present and future applications / BMB Reports 43 (7) : 451 ~ 460
Fernandez-Sesma, A. / 2006 / Influenza virus evades innate and adaptive immunity via the NS1 protein / J. Virol. 80 : 6295 ~ 6304
Abed, Y. / 2011 / The 2009 pandemic H1N1 D222G hemagglutinin mutation alters receptor specificity and increases virulence in mice but not in ferrets / J. Infect. Dis. 204 :
CDC / 2009 / Swine influenza A (H1N1) infection in two children-Southern California, March-April 2009 / MMWR. Morb. Mortal. Wkly. Rep. 58 : 400 ~ 402
Cheol-Min Ghim / 2010 / The art of reporter proteins in science: past, present and future applications / BMB Reports 43 (7) : 451 ~ 460
Fernandez-Sesma, A. / 2006 / Influenza virus evades innate and adaptive immunity via the NS1 protein / J. Virol. 80 : 6295 ~ 6304
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