지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 253 - 258 (6page)
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The dermal papilla cells (DPCs) of hair follicles are known to secrete paracrine factors for follicular cells. Shotgun proteomic analysis was performed to compare the expression profiles of the secretomes of human DPCs and dermal fibroblasts (DFs).
In this study, the proteins secreted by DPCs and matched DFs were analyzed by 1DE/LTQ FTICR MS/MS, semi-quantitatively determined using emPAI mole percent values and then characterized using protein interaction network analysis. Among the 1,271 and 1,188 proteins identified in DFs and DPCs, respectively,1,529 were further analyzed using the Ingenuity Pathway Analysis tool. We identified 28 DPC-specific extracellular matrix proteins including transporters (ECM1, A2M),enzymes (LOX, PON2), and peptidases (C3, C1R). The biochemically-validated DPC-specific proteins included thrombospondin 1 (THBS1), an insulin-like growth factor binding protein3(IGFBP3), and, of particular interest, an integrin beta1subunit (ITGB1) as a key network core protein. Using the shotgun proteomic technique and network analysis, we selected ITGB1, IGFBP3, and THBS1 as being possible hair-growth modulating protein biomarkers. [BMB reports 2012; 45(4):253-258]
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참고문헌 (19)
참고문헌 신청
Carlson, T. R. / 2008 / Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice / Development 135 : 2
Cho, H. J. / 2008 / C-terminal peptide of IGFBP-3, KGRKR, prolongs the proliferative potential of basal keratinocytes / JOURNAL OF DERMATOLOGICAL SCIENCE 50 : 61 ~ 64
Cotsarelis, G. / 1997 / The hair follicle: dying for attention / Am. J. Pathol. 151 : 1505 ~ 1509
Filsell, W. / 1994 / Transfection of rat dermal papilla cells with a gene encoding a temperature-sensitive polyomavirus large T antigen generates cell lines retaining a diffe
Fujie, T. / 2001 / The chemotactic effect of a dermal papilla cell-derived factor on outer root sheath cells / J. Dermatol. Sci. 25 : 206 ~ 212
Cho, H. J. / 2008 / C-terminal peptide of IGFBP-3, KGRKR, prolongs the proliferative potential of basal keratinocytes / JOURNAL OF DERMATOLOGICAL SCIENCE 50 : 61 ~ 64
Cotsarelis, G. / 1997 / The hair follicle: dying for attention / Am. J. Pathol. 151 : 1505 ~ 1509
Filsell, W. / 1994 / Transfection of rat dermal papilla cells with a gene encoding a temperature-sensitive polyomavirus large T antigen generates cell lines retaining a diffe
Fujie, T. / 2001 / The chemotactic effect of a dermal papilla cell-derived factor on outer root sheath cells / J. Dermatol. Sci. 25 : 206 ~ 212
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