지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 59 - 70 (12page)
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초록· 키워드
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Carbon catabolite repression (CCR) is a key regulatory system found in most microorganisms that ensures preferential utilization of energy-efficient carbon sources. CCR helps microorganisms obtain a proper balance between their metabolic capacity and the maximum sugar uptake capability. It also constrains the deregulated utilization of a preferred cognate substrate, enabling microorganisms to survive and dominate in natural environments. On the other side of the same coin lies the tenacious bottleneck in microbial production of bioproducts that employs a combination of carbon sources in varied proportion, such as lignocellulose-derived sugar mixtures.
Preferential sugar uptake combined with the transcriptional and/or enzymatic exclusion of less preferred sugars turns out one of the major barriers in increasing the yield and productivity of fermentation process. Accumulation of the unused substrate also complicates the downstream processes used to extract the desired product. To overcome this difficulty and to develop tailor-made strains for specific metabolic engineering goals, quantitative and systemic understanding of the molecular interaction map behind CCR is a prerequisite. Here we comparatively review the universal and strain-specific features of CCR circuitry and discuss the recent efforts in developing synthetic cell factories devoid of CCR particularly for lignocellulose-based biorefinery. [BMB reports 2012; 45(2): 59-70]
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참고문헌 (21)
참고문헌 신청
Adhya, S. / 1966 / Glucose effect and the galactose enzymes of Escherichia coli: correlation between glucose inhibition of induction and inducer transport / J. Bacteriol. 92
Ajikumar, P. K. / 2010 / Isoprenoid pathway optimization for taxol precursor overproduction in Escherichia coli / Science 330 : 70 ~ 74
Beg, Q. K. / 2007 / Intracellular crowding defines the mode and sequence of substrate uptake by Escherichia coli and constrains its metabolic activity / Proc. Natl. Acad. Sci. U.S
Bruckner, R. / 2002 / Carbon catabolite repression in bacteria: choice of the carbon source and autoregulatory limitation of sugar utilization / FEMS Microbiol. Lett. 209 :
Collier, D. N. / 1996 / Catabolite repression control in the Pseudomonads / Res. Microbiol. 147 : 551 ~ 561
Ajikumar, P. K. / 2010 / Isoprenoid pathway optimization for taxol precursor overproduction in Escherichia coli / Science 330 : 70 ~ 74
Beg, Q. K. / 2007 / Intracellular crowding defines the mode and sequence of substrate uptake by Escherichia coli and constrains its metabolic activity / Proc. Natl. Acad. Sci. U.S
Bruckner, R. / 2002 / Carbon catabolite repression in bacteria: choice of the carbon source and autoregulatory limitation of sugar utilization / FEMS Microbiol. Lett. 209 :
Collier, D. N. / 1996 / Catabolite repression control in the Pseudomonads / Res. Microbiol. 147 : 551 ~ 561
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